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2011 | 58 | 4 |
Tytuł artykułu

Cytotoxicity of PP(Arg)2- and Hp(Arg)2-mediated photodynamic therapy and early stage of apoptosis induction in prostate carcinoma in vitro

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Języki publikacji
Porphyrin photosensitizers tend to localize in mitochondria. The depolarization of mitochondrial membrane is one of the early stages of apoptosis and Laser Scanning Fluorescence Microscopy allows to determine changes in transmembrane mitochondrial potential under influence of PDT depending on the kind of photosensitizer (PP(Arg)2, Hp(Arg)2), the energy dose (5, 10, 30 and 50 J/cm2) and time periods (24 and 48 hours after irradiation) in the LNCaP (lymphonodal metastasis of prostate carcinoma, the androgen dependent cell line). Cyototoxicity induced by PP(Arg)2- and Hp(Arg)2-based PDT depending on energy dose and time after irradiation in prostate carcinoma is determined with MTT. Generally, it was shown that lower energy doses induce greater changes in transmembrane mitochondrial potential. Hp(Arg)2-based PDT was more effective causing greater mitochondrial membrane depolarization and cell viability decrease in comparison to PP(Arg)2-mediated PDT (in the case of maximal nontoxic photosensitizer doses used).
Opis fizyczny
  • Institute of Chemistry, Military University of Technology, Warsaw, Poland
  • Boyle P, Ferlay J (2005) Cancer incidence and mortality in Europe. Ann Oncol 16: 481-88. 
  • Brown SB, Brown EA (2004) The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol 5: 497-508. 
  • Buja LM, Eigenbrodt ML, Eigenbrodt EH (1993) Apoptosis and necrosis. Basic types and mechanisms of cell death. Arch Pathol Lab Med 117: 1208-14. 
  • Buytaert E, Dewaele M, Agostinis P (2007) Molecular effectors of multiple cell death pathways initiated by photodynamic therapy. Biochim Biophys Acta 1776: 86-107. 
  • Castano AP, Demidova TN, Hamblin MR (2005a) Mechanisms in photodynamic therapy: part three-photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. Photodiagnosis Photodyn Ther 2: 91-106.
  • Castano AP, Demidova TN, Hamblin MR (2005b) Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death. Photodiagnosis Photodyn Ther 2: 12-23.
  • Chen LB (1988) Mitochondrial membrane potential in living cells. Annu Rev Cell Dev Biol 4: 155-181.
  • Dellinger M (1996) Apoptosis or necrosis following photofrin photosensitization: influence of the incubation protocol. Photochem Photobiol 64: 182-187. 
  • Desagher S, Martinou JC (2000) Mitochondria as the central control point of apoptosis. Trends Cell Biol 10: 369-377. 
  • Furrer P, Gurny R (2010) Recent advances in confocal microscopy for studing drug delivery to the eye: concepts and pharmaceutical applications. Eur J Pharm Biopharm 74: 33-40. 
  • Gittes RF (1991) Carcinoma of the prostate. N Engl J Med 324: 236-245. 
  • Gomer CJ, Ferrario A, Luna MC, Rucker N, Wong S (1990) Basic mechanisms and subcellular targets related to PDT. SPIE 6: 139-52.
  • Graczyk A (1999) Photodynamic diagnosis and treatment of cancer. 1st edn, pp. 21-159. Bellona, Publishing House, Warszawa (in Polish).
  • Graczyk A, Konarski J (1995) Hematoporphyrin derivatives complex salts and their use in the detection and treatment of neoplasm. Patent 5.451.599 US.
  • Graczyk A, Kwaśny M, Shu Y (2002) Diaminoacid derivatives of protoporphyrine used as photosensitizers in photodynamic method of tumor diagnosis and treatment. Proc of SPIE 5229: 91-96.
  • Green DR (1999) Apoptotic pathways: the roads to ruin. Cell 96: 695-698.
  • Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281: 1309-1312. 
  • Henderson BW, Dougherty TJ (1992) How does photodynamic therapy work? Photochem Photobiol 55: 145-157. 
  • Hilf R, Gibson SL, Murant RS, Cecker TL, Bryant RG (1987) Mitochondria in cancer cells as targets of photodynamic therapy. SPIE 847: 2-10.
  • Hilf R, Smail DB, Murant RS, Leakey PB, Gibson SL (1984) Hematoporphyrin derivative-induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230AC mammary adenocarcinoma of rats. Cancer Res 44: 1483-148. 
  • Isaacs WB, Bova GS, Morton RA et al. (1995) Molecular biology of prostate cancer progression. Cancer Surv 23: 19-32. 
  • Juzeniene A, Moan J (2007a) The history of PDT in Norway Part one: identification of basic mechanisms of general PDT. Photodiagnosis Photodyn Ther 4: 3-11.
  • Juzeniene A, Moan J (2007b) The history of PDT in Norway Part II. Recent advances in general PDT and ALA-PDT. Photodiagnosis Photodyn Ther 4: 80-87.
  • Kessel D (2006) Death pathways associated with photodynamic therapy. Med Laser Appl 21: 219-224. 
  • Kessel D (2004) Photodynamic therapy: from beginning. Photodiagnosis Photodyn Ther 1: 3-7.
  • Kessel D, Dougherty TJ (1999a) Agents used in photodynamic therapy. Contemp Pharmacother 10: 19-24.
  • Kessel D, Luo Y (1999b) Photodynamic therapy: a mitochondrial inducer of apoptosis. Cell Death Differ 6: 28-35. 
  • Kessel D, Luo Y, Deng Y, Chang CK (1997) The role of subcellular localization in initiation of apoptosis by photodynamic therapy. Photochem Photobiol 65: 422-426. 
  • Kowaltowski AJ, Castilho RF (1997) Ca2+ acting at the external side of the inner mitochondrial membrane can stimulate mitochondrial permeability transition induced by phenylarsine oxide. Biochim Biophys Acta 1322: 221-229. 
  • Kwitniewski M, Kunikowska D, Dera-Tomaszewska B, Tokarska-Pietrzak E, Dziadziuszko H, Graczyk A, Głośnicka R (2005) Influence of diamino acid derivatives of protoporphyrin IX on mouse immunological system: preliminary results. J Photochem Photobiol B 81: 129-135. 
  • Kwitniewski M, Juzeniene A, Ma LW, Glosnicka R, Graczyk A, Moan J (2009) Diamino acid derivatives of PPIX as potential photodensitizers for photodynamic therapy of squamous cell carcinoma and prostate cancer: in vitro studies. J Photochem Photobiol B 94: 214-222. 
  • Lee JA (2001) Prostate cancer: biology genetics and the therapeutics. Lancet Oncol 2: 248.
  • Li G, Szewczuk MR, Pottier RH, Kennedy JC (1999) Effect of mammalian cell differentiation on response to exogenous 5-aminolevulinic acid. Photochem Photobiol 69: 231-235. 
  • Luo Y, Chang CK, Kessel D (1996) Rapid initiation of apoptosis by photodynamic therapy. Photochem Photobiol 63: 528-534. 
  • Masters BR (1995) Confocal microscopy: history, principles, instruments and some applications to the living eye. Mol a Cell Biophys 8: 243-249.
  • Mauzerall DC (1998) Evolution of porphyrins. Clin Dermatol 16: 195-201. 
  • McConkey DJ (1998) Biochemical determinants of apoptosis and necrosis. Toxicol Lett 99: 157-168. 
  • Misiewicz I, Skupińska K, Kasprzycka-Guttman T (2003) Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells. Oncol Rep 10: 2045-2050. 
  • Misiewicz I, Skupińska K, Kowalska E, Lubiński J, Kasprzycka-Guttman T. (2004) Sulforaphane-mediated induction of a phase 2 detoxifyng enzyme NAD(P)H: quinone reductase and apoptosis in human lymphoblastoid cells. Acta Biochim Pol 51: 711-721. 
  • Misiewicz-Krzemińska I, Skupińska K, Graczyk A, Kasprzycka-Guttman T (2009) Influence of protoporphyrin IX amino acid substituents on affinity to human breast adenocarcinoma MCF-7 cells. Biotech Histochem 84: 17-23. 
  • Morgan J, Oseroff AR (2001) Mitochondria-based photodynamic anti-cancer therapy. Adv Drug Deliv Rev 49: 71-86. 
  • Noodt BB, Berg K, Stokke T, Peng Q, Nesland JM (1996) Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX. Br J Cancer 74: 22-29. 
  • Nowak-Stępniowska A, Małecki M, Wiktorska K, Romiszewska A, Graczyk A (2011) Inhibition of cell growth induced by photosensitizer PP(Arg)2-mediated photodynamic therapy in human breast and prostate cell lines. Part I. Photodiagnosis Photodyn Ther 8: 39-48. 
  • Ochsner M (1997) Photophysical and photobiological processes in the photodynamic therapy of tumors. J Photochem Photobiol B 39: 1-18. 
  • Oleinick NL, Evans HE (1998) The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat Res 150 (Suppl. 5): 146-156. 
  • Oleinick NL, Morris R, Belichenko I. (2002) The role of apoptosis in response to photodynamic therapy: what, where, why how. Photochem. Photobiol. Sci 1: 1-21. 
  • Otsuki Y (2000) Various methods of apoptosis detection. Acta Histochem Cytochem 33: 235-241.
  • Palmer AM, Greengrass PM, Cavalla D (2000) The role of mitochondria in apoptosis. Drug News Perspect 13: 378-384. 
  • Pass H (1993) Photodynamic therapy in oncology: mechanisms and clinical use. J Natl Cancer Inst 85: 443-456. 
  • Pedersen PL (1987) Tumor mitochondria and the bioenergetics of cancer cells, progress in experimental tumor research, membrane anomalies of tumor cells; vol 22, Karger S ed, pp 190-274. Wallach DFH, Basel.
  • Plaetzer K, Kiesslich T, Verwanger T, Krammer B (2003) The modes of cell death induced by PDT: an overview. Med Laser Appl 18: 7-19.
  • Ponder BA (2001) Cancer genetics. Nature 411: 336-341. 
  • Raymond B (1999) Photodynamic therapy in historical perspective. Contemp Pharmacother 10: 1-14.
  • Reers M, Smith TW, Chen LB (1991) J-Aggregate formation of a carbocyanine as a quantitative fluorescent indicator of a membrane potential. Biochemistry 30: 4480-4486. 
  • Ryter SW, Tyrrell RM (1999) The heme synthesis and degradation pathways: role in oxidant sensitivity. Free Rad Biol Med 28: 289-309. 
  • Schuitmaker JJ, Baas P, van Leengoed HL, van der Meulen FW, Star WM, van Zandwijk N (1996) Photodynamic therapy: a promising new modality for the treatment of cancer. J Photochem Photobiol B 34: 3-12. 
  • Sharman WM, Allen CM, van Lier JE (1999) Photodynamic therapeutics: basic principles and clinical applications. Therapeutic Focus 11: 1359-6446.
  • Sheppard CJR (1993) Confocal microscopy: Principles, practice and options, In: Fluorescent and luminescent probes for biological activity, A practical guide to technology for quantitative real time analysis. Mason WT ed, pp 229-236. Academic Press, London.
  • Shi Y (2001) A structural view of mitochondrial-mediated apoptosis. Nat Struct Biol 8: 394-401. 
  • Skulachev VP (2000) Mitochondria in the programmed death phenomena a principle of biology: "It is better to die than to be wrong". Life 49: 365-373. 
  • Smiley ST, Reers M, Mottola-Hartshorn C, Lin M, Chen A, Smith TW, Steele GD Jr, Chen LB (1991) Intracellular heterogeneity in mitochondrial membrane potentials reveled by J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA 88: 3671-3675. 
  • Steinberg GD, Carter BS, Beaty TH, et al (1990) Family history and the risk of prostate cancer. Prostate 17: 337-347. 
  • Sternberg ED, Dolphin D (1998) Porphyrin-based photosensitizers for use in photodynamic therapy. Tetrahedron 54: 4151-4202.
  • Suresh S (2007) Biomechanics and biophysics of cancer cells. Acta Biomater 3: 413-438. 
  • You Y, Gibson SL, Detty MR (2006) Phototoxicity of a core-modified porphyrin and induction of apoptosis. J Photochem Photobiol B 85: 155-162. 
  • Yow CM, Mak NK, Leung AW, Huang Z (2006) Induction of early apoptosis in human nasopharyngealcarcinoma cells by mTHPC-mediated photocytotoxicity. Photodiagnosis Photodyn Ther 6: 122-127. 
  • Żołądek T, Nhi NB, Jagiełło I, Graczyk A, Rytka J (1997) Diamino acid derivatives of porphyrins penetrate into yeast cells, induce photodamage but have no mutagenic effect. Photochem Photobiol 66: 253-259. 
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