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2009 | 69 | 3 |
Tytuł artykułu

Warsaw high alcohol-preffering (WHP) and low alcohol-preferring (WLP) rats differ in behavioral and midbrain dopamine systems' responses to morphine

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Rats were given 14 “daily” (6 doses/week) s.c. doses of 0.9% NaCl (Sal), morphine (Mor), or methadone (Met), then left untreated for 14 days, and fi nally challenged with Mor, except that half each of the Sal groups were given Sal instead. All the rats were then tested for open fi eld behavior, and were sacrifi ced 2 h post-challenge. Striatal (CPu), accumbal (Acb), sensorimotor cortex (S1) and prefrontal cortex contents of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 3-methoxytyramine (3 MT, assessed only in the CPu and Acb) were measured by HPLC. Analysis of total distance covered by the rats showed Mor and Met-induced sensitization to Mor in the WHP rats only, whereas the distance covered in the central part of the test arena was signifi cantly affected (increased) only by the Mor pretreatment and only in the WHP rats. There was no signifi cant between-line or treatment-related difference in DA content, and no signifi cant between-line difference in baseline DA metabolite contents, except that S1 HVA content was signifi cantly higher in drug-naive WLP rats than in drug-naive WHP rats. HVA and – to a lesser extent – DOPAC contents were, in general, higher in the Mor-challenged rats than in the respective Sal-treated controls, but the differences were more pronounced in the WLP rats than in their WHP counterparts, whereas the opioid -pretreated WHP rats showed higher CPu and Acb 3 MT contents than their WLP counterparts.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.352
Twórcy
autor
  • Department of Neurolchemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Neurolchemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Experimental Pharmacology, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
autor
  • Department of Neurolchemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
  • Department of Neurolchemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Neurolchemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Neurolchemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-067670bc-23b9-40be-9a4f-971a0f7799e5
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