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2017 | 20 | 3 |

Tytuł artykułu

Influence of long-term oral application of quinolones on the ECG curve in dogs

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the study was to analyse the influence of enrofloxacin and pradofloxacin administered orally for 14 days on the ECG in dogs. The ECG was performed before and after a 14 day period of quinolone administration. There was an increase in the QTc and the TpTe interval in the group treated with quinolones. QTc was prolonged by 24 ms (p=0.001). The TpTe interval was shortened, on average, by 6.55 ms (p=0.048). In the group treated with enrofloxacin, QTc was prolonged by 16.27 ms (p=0.006) and the TpTe interval was shortened by 9.64 ms (p=0.050), the TpTe/QT index was reduced by 0.034 (p=0.050) on average. In dogs treated with pradofloxacin, QTc was prolonged by 21.55 ms (p=0.012) on average. The results suggest that a prolonged administration of quinolones can increase the risk of arrhythmias. Furthermore, different generations of these drugs increase this risk to various degrees. The study proved that second generation quinolones, such as enrofloxacin, significantly change the phase of depolarization and repolarization of the ventricles, at the same time increasing the risk of ventricular arrythmia. Pradofloxacin does not change the TpTe and TpTe/QT values, so it is safer in use.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

20

Numer

3

Opis fizyczny

p.567-572,ref.

Twórcy

autor
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland

Bibliografia

  • Agudelo-Ramirez CF, Scheer P, Tomenendálová J (2012) Effects of parenteral administration of enrofloxacin on electrocardiographic parameters in hospitalized dogs. Acta Vet Brno 81: 409-414.
  • Antzelevitch C (2004) Arrhythmogenic mechanism of QT prolonging drugs: is QT pro- longation really the problem? J Electrocardiol 37: 15-24.
  • Antzelevitch C (2008) Drug-induced spatial dispersion of repolarization. Cardiol J 15: 100-121.
  • Barbhaiya C, Po JR, Hanon S, Schweitzer P (2013) Tpeak – Tend and Tpeak – Tend /QT ratio as markers of ventricular arrhythmia risk in cardiac resynchronization therapy patients. Pacing Clin Electrophysiol 36: 103-108.
  • Boothe DM, Boeckh A, Boothe HW, Wilkie S (2010) Tissue concentrations of enrofloxacin and ciprofloxacin in anesthetized dogs following single intravenous administration. Vet Therapeutics 2: 120-128.
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  • Castro Hevia J, Antzelevitch C, Tornés Bárzaga F, Dorantes Sánchez M, Dorticós Balea F, Zayas Molina R, Quiñones Pérez MA, Fayad Rodríguez Y (2006) Tpeak-Tend and Tpeak-Tend Dispersion as Risk Factors for Ventricular Tachycardia/Ventricular Fibrillation in Patients with the Brugada Syndrome. J Am Coll Cardiol 47: 1828-1834.
  • Chanoit GP, Schneider M, Woehrlé F, Lefebvre HP (2005) Effect of marbofloxacin on cardiovascular variables in healthy isoflurane-anesthetized dogs. Am J Vet Res66: 2090-2094.
  • Chiang CE (2006) Drug-induced long QT syndrome. J Med Biol Eng 26: 107-113.
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  • Ghaffari MS, Parsamehr R (2009) The effects of intravenous ciprofloxacin on the electrocardiogram of healthy dogs. Vet Res Commun 33: 987-990.
  • Kallergis EM, Goudis CA, Simantirakis EN, Kochiadakis GE, Vardas PE (2012) Mechanisms, risk factors, and management of acquired long QT syndrome: a comprehensive review. Scientific World Journal 2012: 212178.
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  • Piccirillo G, MagríD, Pappadá MA, Maruotti A, Ogawa M, Han S, Joung B, Rossi P, Nguyen BL, Lin SF, Chen PS (2012) Autonomic nerve activity and the short-term variability of the Tpeak-Tend interval in dogs with pacing-induced heart failure. Heart Rhythm 9: 2044-2050.
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  • Shimizu M, Ino H, Okeie K, Yamaguchi M, Nagata M, Hayashi K, Itoh H, Iwaki T, Oe K, Konno T, Mabuchi H (2002) T-peak to T-end interval may be a better predictor of high-risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin I mutation than QT dispersion. Clin Cardiol 25: 335-339.
  • Toyoshima S, Kanno A, Kitayama T, Sekiya K, Nakai K, Haruna M, Mino T, Miyazaki H, Yano K, Yamamoto K (2005) QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals. J Pharmacol Sci 99: 459-471.
  • Vormberge T, Hoffmann M, Himmel H (2006) Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve. J Pharmacol Toxicol Methods 54: 130-140.
  • Wang J, Della Penna K, Wang H, Karczewski J, Connolly TM, Koblan TS, Bennett PB, Salata JJ (2003) Functional and pharmacological properties of canine ERG potassium channels. Am J Physiol Heart Circ Physiol 284: 256-267.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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