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1

Genomic instability in the PARK2 locus is associated with Parkinson’s disease

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Ambroziak W., Koziorowski D., Gorka-Skoczylas P., Potulska-Chromik P., Slawek J., Hoffman-Zacharska D.
Journal of Applied Genetics
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2015
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tom 56
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nr 4
2

m levels of hepcidin and interleukin 6 in Parkinson’s disease

100%
Kwiatek-Majkusiak J., Geremek M., Koziorowski D., Tomasiuk R., Szlufik S., Friedman A.
Acta Neurobiologiae Experimentalis
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2020
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tom 80
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nr 3
Neurodegeneration in Parkinson’s disease (PD) includes processes of chronic inflammation and oxidative stress which are related to dysregulation in the homeostasis of iron metabolism. Hepcidin is a peptide hormone responsible for systemic iron homeostasis and simultaneously the inflammatory response protein, induced in response to interleukin 6 (IL‑6). We assessed the serum concentration of hepcidin and IL‑6 in the groups of patients with PD treated only pharmacologically with optimal individualized therapy (MT) and treated additionally with deep brain stimulation (DBS), compared to the control group. The serum concentrations of hepcidin and IL‑6 in the group of all PD patients were significantly higher than in the control group. In the group of PD patients treated with DBS hepcidin and IL‑6 concentrations were significantly higher compared to the control group. Additionally, the positive correlations between serum hepcidin and IL‑6 were found in the PD (MT and DBS) and PD‑DBS group. The obtained results may indicate the influence of immunological mechanisms on iron metabolism and oxidative stress, in particular when the inflammatory process is more active in the DBS‑treated group. This effect can be protective as well as neurodegenerative.
3

Relationships between typical histopathological hallmarks and the ferritin in the hippocampus from patients with Alzheimer’s disease

100%
Kwiatek-Majkusiak J., Dickson D. W., Tacik P., Aoki N., Tomasiuk R., Koziorowski D., Friedman A.
Acta Neurobiologiae Experimentalis
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2015
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tom 75
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nr 4
Oxidative stress is one of the possible mechanisms of neurodegeneration. One of the elements of this mechanism are altered iron homeostasis and changes concerning of iron metabolism regulatory proteins. The primary iron storage protein in cells is ferritin, composed of heavy (H) and light (L) chains. In brain tissue neurons contain mainly ferritin H-chains, whereas glial cells are rich in L-chains. To the best of our knowledge, this is the first study that compares structure of ferritin and histopathological hallmarks in hippocampal tissue affected by the pathological process of Alzheimer’s disease (AD). Our data indicate a statistically significant correlation between the concentration of L chains of ferritin, the H/L ratio and the amount of senile plaques in the subiculum, CA1 and CA4 sectors of the hippocampus (p<0.001, p=0.025, p=0.029). A significant correlation was also found between the concentration of L-ferritin and neuronal loss (p=0.0026). These findings indicate an important role of ferritin light chains in neurodegeneration, that is linked to chronic inflammation processes and the associated activation of the microglia rich of L chains.
4

Parkinson's disease leads to distorted interaction of episodic and working memory systems

68%
Gawrys L., Szatkowska L., Pilacinski A., Piatkowska-Janko E., Bogorodzki P., Wolak T., Friedman A., Sienkiewicz J., Koziorowski D., Janik P., Jamrozik Z., Krolicki L., Andrysiak R., Kulinski R., Kaczmarek L.
Acta Neurobiologiae Experimentalis
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2009
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tom 69
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nr 3
Patients with Parkinson’s disease (PD) exhibit impairments in executive function and working memory. As opposed to motor symptoms of the disease the physiological origins of cognitive defi cits are not well understood. The aim of the present study was to delineate mechanisms of cognitive impairment in PD using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI). Twenty-two patient and 10 matched control subjects accomplished Wisconsin Card Sorting Test (WCST) – standard clinical measure of executive function and then underwent fMRI during performance of the N-Back working memory task.The correlation analysis comparing BOLD signal intensity changes with number of categories achieved in WCST revealed a signifi cant positive correlation within supramarginal gyrus, inferior parietal gyrus, middle and inferior frontal gyrus and caudate nucleus. Signifi cant negative correlations with executive impairment were observed within fusiform and parahippocampal gyrus, as well as enthorhinal and perirhinal cortex. These results suggest that cognitive impairment in PD may origin in consequence of distorted interaction between episodic and working memory systems.
5

The neural correlates of specific executive dysfunctions in Parkinson’s disease

68%
Gawrys L., Falkiewicz M., Pilacinski A., Riegel M., Piatkowska-Janko E., Bogorodzki P., Wolak T., Andrysiak R., Krolicki L., Kulinski R., Koziorowski D., Janik P., Rymarczyk K., Grabowska A., Kaczmarek L., Szatkowska I.
Acta Neurobiologiae Experimentalis
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2014
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tom 74
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nr 4
Several functional neuroimaging studies in patients with Parkinson's disease (PD) have suggested that changes in the fronto-parietal-striatal networks are associated with deficits in executive functioning. However, executive functions (EF) are multifaceted and include three dissociable components: working memory, response inhibition, and task-switching. This study investigated which component of executive functioning is most strongly associated with fronto-parietal-striatal efficiency in PD. PD patients (with and without executive dysfunction), and age-matched healthy subjects, completed a battery of cognitive tests previously shown to discriminate among the three EF components. Principal component analysis conducted on the selected cognitive test variables yielded three expected EF components. The component scores were used in regression analysis to assess the relationship between the EF efficiency and blood oxygenation level-dependent (BOLD) signal related to performing the n-back, an experimental task that draws upon multiple components of executive functioning: working memory, response inhibition, and task-switching. We found distinct neural correlates of specific executive dysfunctions in patients with PD. However, all of them seem to be associated with fronto-parietal-striatal efficiency.
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