Polymorphism of AA-NAT gene and its relationship with litter size of Jining Grey goat of China

• Autorzy: Chu M. , Yan Y. , Wang P. , Guligena , Yang H. , Hao G. , Yu J. , Tang Q. , Feng T. , Cao G. , Huang D. , Di R. , Liu Q. , Li N.
• Języki publikacji: EN

Abstrakty

EN

The polymorphisms of arylalkylamine-N-acetyltransferase (AA-NAT) gene in high-prolificacy Jining Grey goat, medium-prolificacy Boer goat and low-prolificacy Liaoning Cashmere, Inner Mongolia Cashmere and Angora goats were detected to analyse their relationships with litter size.Primers (P1-P5) were designed to detect the polymorphisms by PCR-SSCP and PCR-RFLP. For P2,AA, AB and BB genotypes were detected. Sequencing revealed one silent mutation (T132C) of AANAT gene in BB in comparison to AA. For P3, CC and CD genotypes were detected and sequencing revealed one mutation (C265T) of AA-NAT gene in CD in comparison to CC, and this mutation resulted in an amino acid change of Arg→Cys (R89C). The Jining Grey does with genotype CD delivered by 0.56 kids (P<0.05) more than those with CC genotype. For P5, EE, EF and FF genotypes were detected and sequencing revealed one mutation (C586T) of AA-NAT gene in FF in comparison to EE. This mutation caused an amino acid change of Arg→Trp (R196W). For both P2 and P5, the differences in litter size among three genotypes were not significant in Jining Grey goats (P>0.05).These results preliminarily indicate that allele D at the C265T locus of AA-NAT gene is a potential marker in genetic improvement of litter size in goats.

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2013
• Tom: 31
• Numer: 1
• Opis fizyczny: p.15-26,fig.,ref.

Twórcy

autor

Chu M.

• Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

autor

Yan Y.

• Bioengineering College, Chongqing University, Chongqing 400030, China

autor

Wang P.

• Bioengineering College, Chongqing University, Chongqing 400030, China

autor

Guligena

• Animal Science Institute, Xinjiang Academy of Animal Sciences, Urumqi 830000, China

autor

Yang H.

• Animal Science Institute, Xinjiang Academy of Animal Sciences, Urumqi 830000, China

autor

Hao G.

• Animal Science Institute, Xinjiang Academy of Animal Sciences, Urumqi 830000, China

autor

Yu J.

• Animal Science Institute, Xinjiang Academy of Animal Sciences, Urumqi 830000, China

autor

Tang Q.

• Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

autor

Feng T.

• Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

autor

Cao G.

• Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

autor

Huang D.

• Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

autor

Di R.

• Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

autor

Liu Q.

• Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

autor

Li N.

• Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

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