Parkinson's disease leads to distorted interaction of episodic and working memory systems

• Autorzy: Gawrys L. , Szatkowska L. , Pilacinski A. , Piatkowska-Janko E. , Bogorodzki P. , Wolak T. , Friedman A. , Sienkiewicz J. , Koziorowski D. , Janik P. , Jamrozik Z. , Krolicki L. , Andrysiak R. , Kulinski R. , Kaczmarek L.
• Języki publikacji: EN

Abstrakty

EN

Patients with Parkinson’s disease (PD) exhibit impairments in executive function and working memory. As opposed to motor symptoms of the disease the physiological origins of cognitive defi cits are not well understood. The aim of the present study was to delineate mechanisms of cognitive impairment in PD using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI). Twenty-two patient and 10 matched control subjects accomplished Wisconsin Card Sorting Test (WCST) – standard clinical measure of executive function and then underwent fMRI during performance of the N-Back working memory task.The correlation analysis comparing BOLD signal intensity changes with number of categories achieved in WCST revealed a signifi cant positive correlation within supramarginal gyrus, inferior parietal gyrus, middle and inferior frontal gyrus and caudate nucleus. Signifi cant negative correlations with executive impairment were observed within fusiform and parahippocampal gyrus, as well as enthorhinal and perirhinal cortex. These results suggest that cognitive impairment in PD may origin in consequence of distorted interaction between episodic and working memory systems.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.344

Twórcy

autor

Gawrys L.

• Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Szatkowska L.

• Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Pilacinski A.

• Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Piatkowska-Janko E.

• Warsaw University of Technology, Institute of Radioelectronic, Warsaw, Poland

autor

Bogorodzki P.

• Warsaw University of Technology, Institute of Radioelectronic, Warsaw, Poland

autor

Wolak T.

• Institute of Physiology and Pathology of Hearing, Warsaw, Poland

autor

Friedman A.

• Medical University of Warsaw, Warsaw, Poland

autor

Sienkiewicz J.

• Medical University of Warsaw, Warsaw, Poland

autor

Koziorowski D.

• Medical University of Warsaw, Warsaw, Poland

autor

Janik P.

• Medical University of Warsaw, Warsaw, Poland

autor

Jamrozik Z.

• Medical University of Warsaw, Warsaw, Poland

autor

Krolicki L.

• Medical University of Warsaw, Warsaw, Poland

autor

Andrysiak R.

• Medical University of Warsaw, Warsaw, Poland

autor

Kulinski R.

• Medical University of Warsaw, Warsaw, Poland

autor

Kaczmarek L.

• Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland