Modulation of testicular functions by testicular opioid peptides

• Autorzy: Gerendai I.
• Języki publikacji: EN

Abstrakty

EN

The possible physiological role of testicular opioid peptides in the control of testicular functions has been studied. In neonatal rats in tratest icular administration of opiate receptor antagonists (naloxone, nalmefene) stimulates Sertoli cell proliferation and secretion. Both in adult and neonatal rats local injection of the testis with opiate receptor antagonists or with ß-endorphin antiserum results in a decrease in steroidogenesis in long-term studies. Treatment of neonatal testis with an enkephalin analogue induces a short-term suppression of testosterone secretion. Further studies were carried out to investigate whether the above described local effects of opiate agonist or antagonist on testicular function are under the regulatory control of testicular nerves. Partial denervation of the testis was performed by testicular injection of 6-hydroxydopamine (a neurotoxin degenerating sympathetic neural structures) or by vasectomy (cutting the inferior spermatic nerve). If testicular administration of opioid agonist or antagonist was combined with partial denervation of the testis, the effects of pharmacological agents influencing testicular opioid level were not evident. The data indicate that opioid peptides synthesized in the testis are components,of the intratest icular regulatory system and that local opioid actions are modulated by testicular nerves.

Słowa kluczowe

EN

opioid peptide; testicular function; rat; testis; opiate receptor; naloxone; Sertoli cell; beta-endorphin; steroidogenesis; proopiomelanocortin; Leydig cell

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1991
• Tom: 42
• Numer: 4
• Opis fizyczny: p.427-437,fig.,ref.

Twórcy

autor

Gerendai I.

• 2nd Department of Anatomy, Semmelweis University Medical School, Tuzolto 58, H-1094, Budapest, Hungary

Bibliografia

• 1. Tsong SD, Phillips DM, Halmi N, Kriegei DT, Bardin CW. ß-endorphin is present in the male- repioductive tract of five species. Biol Reprod 1982; 28: 757-764.
• 2. Pintar JE, Schachter В, Herman AB, Durgerian S, Krieger DT. Characterization and localization of proopiomelanocortin messengei RNA in the adult rat testis. Science 1984; 225: 632-634.
• 3. Gizang-Ginsberg E, Wolzemuth DJ. Localization of mRNAs in mouse testes by in situ hybridization: distribution of tubulin and developmental stage specificity of pro-opiomelanocortin transcripts. Dev Biol 1985; 111: 293-305.
• 4. Douglas J, Cox B, Quinn B, Civelli O, Herbert E. Expression of the prodynorphin gene in male and female mammalian reproductive tissues. Endocrinology 1987; 120: 707-713.
• 5. Kilpatrick DL, Howells RD, Noe M, Bailey LC, Udenfriend S. Expression of proenkephalinlike mRNA and its peptide products in the mammalian testis and ovary. Proc Natl Acad Sci USA 1985; 82: 7467-7469.
• 6. Kew D, Kilpatrick DL. Expression and regulation of the proenkephalin gene in rat Sertoli cells. Mol Endocrinol 1989; 3: 179-182.
• 7. Shaha C, Liotta AS, Kieger DT, Bardin CW. The ontogeny of immunoreactive ß endorphin in the fetal, neonatal and pubertal testes from mouse and hamster. Endocrinology 1984; 114: 1584-1591.
• 8. Valenca MM, Negro Vilar A. Proopiomelanocortin-derived peptides in testicular interstitial fluid: characterization and changes in secretion after human chorionic gonadotropin or luteinizing hormone-releasing hormone analog treatment. Endocrinology 1986; 118: 32-37.
• 9. Fabbri A, Knox G, Buczko E, Dufau ML. ß-endorphin production by the fetal Leydig cell: regulation and implications for paracrine control of Sertoli cell function. Endocrinology 1988; 122: 749-755.
• 10. Chen CLC, Madigan MB. Regulation of testicular proopiomelanocortion gene expression. Endocrinology 1987; 121: 590-596.
• 11. Gerendai I, Nemeskéri A, Csernus V. Naloxone has a local effect on the testis of immature rats. Andrologia 1983; 15: 398-403.
• 12. Gerendai I, Shaha C, Gunsalus GL, Bardin CW. The effects of opiate receptor antagonists suggest that testicular opiates regulate Sertoli and Leydig cell function in the neonatal rat. Endocrinology 1986; 118: 2039-2044.
• 13. Gerendai I, Shaha C, Thau R, Bardin CW. Do testicular opiates regulate Leydig cell function? Endocrinology 1984; 115: 1645-1647.
• 14. Bajusz S, Rónai AZ, Székely JJ, Graf L, Dunai-Kovács Zs, Berzétei, I. A superactive antinociceptive peptapeptide (Dmet² Pro⁵) enkephalinamide. FEBS Lett 1977; 76: 91-92.
• 15. Gerendai I, Nemeskeri Á, Csernus V. Intratesticular injection of (D-Met² -Pro⁵ ) enkephalinamide suppresses testosterone secretion of the testis of immature rat. Regul Pept 1990; 27: 107-115.
• 16. Anakwe OO, Moger WH. Catecholamine stimulation of androgen production by rat Leydig cells. Interactions with luteinizing hormone and luteinizing hormone-releasing hormone. Biot Reprod 1986; 35: 806-814.
• 17. Moger WH, Murphy PR, Casper RF. Catecholamine stimulation of androgen production by mouse interstitial cells in primary culture. J Antrol 1982; 3: 227-231.
• 18. Moger WH, Murphy PR. ß-adrenergic agonist induced androgen production during primary culture of mouse Leydig cells. Arch Androl 1983; 10: 135-142.
• 19. Nagai K, Murano S, Minokoshi Y, Okuda H, Kinotuni M. Effect of denervation and local 6-hydroxydopamine injection on testicular growth in rais. Experientia 1982; 38: 592- 594.
• 20. Gerendai I, Nemeskéri Á, Csernus V. Depending on the dose 6-OHDA stimulates or inhibits the testis of immature rats. Exp Clin Endocrinol 1984; 84: 27-36.
• 21. Gerendai I, Nemeskéri Á, Csernus V, Halász B. Effect of simultaneous injection of 6-hydroxydopamine and naloxone on the testis of neonatal rats. Andrologia 1989; 21: 449-455.
• 22. Frankel AI, Mock EJ, Chapman JC. Hypophysectomy and hemivasectomy can inhibit the testicular hemicastration response of the mature rat. Biol Reprod 1984; 30: 804-808.
• 23. Gerendai I, Nemeskéri Á, Csernus V. The effect of neonatal vasectomy on testicular function. Andrologia 1986; 18: 353-359.
• 24. Frankel AI, Rayn EL. Testicular innervation is necessary for the response of plasma testosterone levels to acute stress. Biol Reprod 1981; 24 : 491-495.
• 25. Pfeiffer A, Herz A. Endocrine actions of opioids. Horm Metab Res 1984; 16: 389-397.
• 26. Drouva SV, Epelbaum L, Tapiaara L, Laplante E, Kordon C. Opiate receptors modulate LHRH- and SRIF-release from mediobasal hypothalamic neurons. Neuroendocrinology 1981; 32: 162-166.
• 27. Blank MS, Fabbri A, Catt K, Dufau ML. Inhibition of luteinizing hormone release by morphine and endogenous opiates in cultured pituitary cells. Endocrinology 1986; 118: 2097- 2101.
• 28. Orth JM. FSH-induced cell proliferation in the developing rat is modified by ß-endorphin produced in the testis. Endocrinology 1986; 119: 1876-1878.
• 29. Fabbri T, Tsai Morris CH, Luna S, Fraioli F, Dufau ML. Opiate receptors are present in the rat testis: identification and localization in Sertoli cells. Endocrinology 1985; 117: 2544- 2546.
• 30. Bardin CW, Boitani C, Morris PL, Gerendai I, Chen CLC. The presence of ß-endorphin, alpha MSH and other pro-opiomelano-cortin-derived peptides in peripheral reproductive tissues. Seminars in Reproductive Endocrinology 1987; 5: 145-152.