Raspberry seed extract improves the ferroxidase activity of ceruloplasmin in patients with lower artery chronic total occlusion

• Autorzy: Gryszczynska B. , Iskra M. , Malecka M. , Wielkoszynski T. , Pacholek B. , Gliszczynska-Swiglo A. , Gryszczynska A. , Budzyn-Napierala M. , Kasprzak M. , Strzyzewski K.
• Języki publikacji: EN

Abstrakty

EN

Ceruloplasmin (Cp) is the major antioxidant in plasma, a protein that carries about 95% of the total copper. Multiple biochemical activities of ceruloplasmin have been described, including copper transport or oxidation of Fe(II) to Fe(III) for subsequent uptake by transferrin and ferritin. Reduction of the pool of free Fe(II) ions by Cp prevents the generation of free radicals and reactive oxygen species by oxidation of Fe(II), thus inhibiting the Haber-Weiss reaction. The removal of both free Fe(II) and Fe(III) ions from blood plasma by polyphenols enhances the antioxidant system of the living organism. However, the mechanism of interactions between exo- and endogenous antioxidants is still under consideration. The effect of raspberry seed extract (RSE) on the ferroxidase activity of ceruloplasmin isolated from plasma of patients with chronic arterial occlusion of the lower limbs due to atherosclerosis (CpAO) was investigated. Moreover, the effect of RSE on the ferroxidase activity of Cp isolated from healthy volunteers (CpC) was also estimated. The ferroxidase activity of Cp, expressed as ΔFe(II), was determined by spectrophotometry with the use of the Fe(II) – histidine complex and ferrozine as a chromogenic reagent. The addition of RSE to samples with the same amount of both CpAO or CpC in each caused an increase in ΔFe(II). The polyphenol-rich RSE may assist Cp in the fight against free radicals and reactive oxygen species when the disease occurs due to an excessive use or reduced production of endogenous antioxidants.

Słowa kluczowe

EN

raspberry; seed extract; ferroxidase; enzyme activity; natural antioxidant; atherosclerosis; ceruloplasmin; patient

• Wydawca: -
• Czasopismo: Journal of Elementology
• Rocznik: 2015
• Tom: 20
• Numer: 2
• Opis fizyczny: p.305-317,fig.,ref.

Twórcy

autor

Gryszczynska B.

• Chair of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland

autor

Iskra M.

• Chair of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Poznan, Poland

autor

Malecka M.

• Chair of Food Quality, Poznan University of Economics, Poznan, Poland

autor

Wielkoszynski T.

• Department of Chemistry, Medical University of Sciences Silesia, Zabrze - Rokitnica, Poland

autor

Pacholek B.

• Chair of Food Quality, Poznan University of Economics, Poznan, Poland

autor

Gliszczynska-Swiglo A.

• Chair of Technology and Instrumental Analysis, Poznan University of Economics, Poznan, Poland

autor

Gryszczynska A.

• Medicinal Products and Dietary Supplements Department (QP), Institute of Natural Fibres and Medicinal Plants Quality Control, Poznan, Poland

autor

Budzyn-Napierala M.

• Chair of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Poznan, Poland

autor

Kasprzak M.

• Chair of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Poznan, Poland

autor

Strzyzewski K.

• Chair of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Poznan, Poland

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Identyfikatory

DOI

10.5601/jelem.2014.19.3.662