Neuropeptide analogues as prospective new medicines for cancer pain treatment: Opioid-tachykinin chimera

• Autorzy: Lipkowski A.W. , Kosson D. , Klinowiecka A. , Misicka A.
• Języki publikacji: EN

Abstrakty

EN

Multidrug therapies became routine approach in modern medical treatment protocols. However, simple combinations of drugs have disadvantages, including differences in pharmacological profi les of single drug component. Therefore, over twenty years ago we have proposed development of multitarget medicines as a new avenue of drug discovery. Identifi cation of numerous endogenous components that participate in the formation, transmission, modulation and perception of pain signals offers numerous strategies for the development of new analgesics. One of them is hybridization of opioid pharmacophores with tachykinin receptor ligands. Tachykinins, like substance P (SP) produces both hyperalgesia and, at low doses, a naloxone-sensitive analgesia. Very likely, these opposite effects of SP in the spinal cord, are mediated through activation of various self-regulatory mechanisms. Modulation of tachykinin receptor system is probably signifi cant component of tolerance and dependence development. Therefore, various new opioid agonisttachykinin antagonist and opioid agonist-tachykinin agonist have been synthesized and tested to develop new medicines for chronic pain treatment. The presentation will focus on new group of opioid agonist-tachykinin agonist that expresses strong analgesic activity even after peripheral application. These new compounds are interesting candidates for treatment of chronic pain because they express very low tolerance development properties. Presented studies have been supported in part with EU grant Normolife (LSHC-CT-2006-037733)

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 1
• Opis fizyczny: p.83

Twórcy

autor

Lipkowski A.W.

• Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Kosson D.

• Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Klinowiecka A.

• Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Misicka A.

• Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland