Electrophysiology of GABAergic transmission of single intergeniculate leaflet neurons in rat

• Autorzy: Palus K. , Chrobok L. , Lewandowski M. H.
• Języki publikacji: EN

Abstrakty

EN

The intergeniculate leaflet (IGL) of the thalamus constitutes a small but important part of the neural network controlling circadian activity in rodents. It appears that IGL integrates photic cues from retina with non-photic information originating from different nonspecific brain systems. Subsequently, this integrated signal is passed to the master biological clock - the suprachiasmatic nuclei (SCN). The common neurotransmitter of biological clock neural structures, the y-amino-butyric acid (GABA) is expressed in many, if not all, IGL and SCN neurons. Whole-cell patch clamp in vitro electrophysiological experiments were performed in order to evaluate GABA's influence on single IGL neurons in rat. Most neurons were hyperpolarized by GABA application and this effect was caused by activation of GABAa as well as GABAb receptors. The presence of GABAB receptors in rat's IGL has been suggested for the first time.

Słowa kluczowe

EN

electrophysiology; gamma-aminobutyric acid; biological clock; patch clamp; intergeniculate leaflet; neuron; rat

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: 1
• Opis fizyczny: p.27-35,fig.,ref.

Twórcy

autor

Palus K.

• Department of Neurophysiology and Chronobiology, Institute of Zoology, Jagiellonian University, Krakow, Poland

autor

Chrobok L.

• Department of Neurophysiology and Chronobiology, Institute of Zoology, Jagiellonian University, Krakow,

autor

Lewandowski M. H.

• Department of Neurophysiology and Chronobiology, Institute of Zoology, Jagiellonian University, Krakow,

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