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2013 | 16 | 3 |

Tytuł artykułu

Lymphocytes T and B in rabbits infected with RHD virus

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of this study was to determine the differences in immunological response of animals infected with different antigenic variants of the virus – three haemagglutinating (Vt97, Triptis, Hartmannsdorf) and two non-haemagglutinating (Pv97, 9905 RHDVa). The specific immunological response was measured by the dynamics of changes in the amount of lymphocytes T (with CD5+, CD4+, CD8+, CD25+ receptor) and B (with CD19+ receptor). The study showed differences in immunogenicity of the analysed RHDV antigenic variants, which allowed them to be divided into groups of: more immunogenic strains, including non-haemagglutinating 9905 RHDVa and haemagglutinating Vt97 and Triptis variants; and less immunogenic strains, including the haemagglutinating Hartmannsdorf variant and the non-haemagglutinating Pv97 variant. Such a result may indicate that the agglutination capacity of red blood cells might not be a factor impacting the number of T and B lymphocytes.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

16

Numer

3

Opis fizyczny

p.563-565,ref.

Twórcy

  • Department of Immunology, Faculty of Biology University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland
  • Department of Immunology, Faculty of Biology University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland
autor
  • Department of Immunology, Faculty of Biology University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland

Bibliografia

  • Bradfute SB, Braun DR, Shamblin JD, Geisbert JB, Paragas J, Garrison A, Hensley LE, Geisbert TW (2007) Lymphocyte death in a mouse model of Ebola virus infection. J Infect Dis 196: S296-304.
  • Bradfute SB, Warfield KL, Bavari S (2008) Functional CD8+ T cell responses in lethal Ebola virus infection. J Immunol 180: 4058-4066.
  • Capucci L, Fallacara F, Grazioli S, Lavazza A, Pacciarini ML, Brocchi E (1998) A further step in the evolution of rabbit hemorrhagic disease virus: the appearance of the first consistent antigenic variant. Virus Res 58: 115-126.
  • Hukowska-Szematowicz B, Deptuła W (2008a) Peripheral blood lymphocytes in rabbits infected with Czech strains, CAMPV-562 and CAMPV-558 of RHD virus. Centr Eur J Immunol 33: 8-13.
  • Hukowska-Szematowicz B, Deptuła W (2008b) Dynamics of peripheral blood lymphocytes in rabbits experimentally infected with two Czech strains of RHD virus. Bull Vet Inst Pulawy 52: 23-29.
  • Hukowska-Szematowicz B, Tokarz-Deptuła B, Deptuła W (2005) Lymphocytes T and their subpopulations in peripheral blood in rabbits experimentally infected with two strains of VHD virus (viral haemorrhagic disease). Pol J Environ Stud 14: 550-555.
  • Niedźwiedzka-Rystwej P, Deptuła W (2012) Lymphocyte subpopulations and apoptosis of immune cells in rabbits experimentally infected with a strain of the RHD virus having a variable heamagglutination capacity. Pol J Vet Sci 15: 43-49.
  • Tokarz-Deptuła (2009) Immunity phenomena in rabbits infected with the RHD (rabbit haemorrhagic disease) virus. Pol J Environ Stud 7: 1-81.
  • Tokarz-Deptuła B, Deptuła W (2003) Dynamic alterations in peripheral blood lymphocytes in rabbits experimentally infected with VHD (viral hemorrhagic disease) virus – Polish strain Kr-1. Pol J Vet Sci 6 (3 Suppl): 67-69.
  • Tian L, Liao J, Li JW, Zhou WR, Zhang XL, Wang HN (2007) Isolation and identification of a non-haemagglutinating strain of rabbit hemorrhagic disease virus from China and sequence analysis for the VP60 gene. Virus Genes 35: 745-752.
  • Warfield KL, Olinger G, Deal EM, Swenson DL, Bailey M, Negley DL, Hart MK, Bavari S (2005) Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection. J Immunol 175: 1184-1191.

Typ dokumentu

Bibliografia

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