PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Czasopismo

2016 | 75 | 4 |

Tytuł artykułu

Assessment of femoral neck fractures in the elderly with respect to morphology and mineral density

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Background: Femoral neck fractures are among the major orthopaedic problems seen in the elderly and the annual mortality rate is high. The calcium (Ca) and phosphorus (P) ratio can be used as an indicator of osteoporosis. The purpose of this study is to investigate the microarchitectural structure of the fractured regions of femoral head as well as bone mineral density in female and male patients. Materials and methods: The bone tissues taken from the fractured regions of 10 male and 9 female patients were examined with a scanning electron microscope. Electron probe microanalyses were carried out to measure mineral ratios. Results: The bone trabeculae in the fractured area were thin and the cavities between trabeculae were seen to have transformed to irregular and broad structures. There were small valleculae reflecting osteoclastic activity. The analysis showed that the Ca/P ratio at the fracture site averaged 2.20/1 in women and 2.16/1 in men. As age increased, the percentage values of Ca and P decreased and the Ca/P ratio increased. Conclusions: Although there is no significant difference between the parameters of male and female patients, it seems that men can be affected by osteoporosis as much as women. (Folia Morphol 2016; 75, 4: 536–542)

Słowa kluczowe

Wydawca

-

Czasopismo

Rocznik

Tom

75

Numer

4

Opis fizyczny

p.536-542,fig.,ref.

Twórcy

autor
  • Denizli Health Services Vocational School, Pamukkale University, 20070, Denizli, Turkey
autor
  • Department of Histology and Embryology, Medical Faculty, Erciyes University, Kayseri, Turkey
autor
  • Department of Histology and Embryology, Medical Faculty, Erciyes University, Kayseri, Turkey
autor
  • Department of Histology and Embryology, Medical Faculty, Erciyes University, Kayseri, Turkey

Bibliografia

  • 1. Basle MF, Mauras Y, Audran M, Clochon P, Rebel A, Allain P (1990) Concentration of bone elements in osteoporosis. J Bone Miner Res, 5: 41–47.
  • 2. Bell KL, Loveridge N, Pover J, Garrahan N, Stanton M, Lunt M, Meggit BF, Reeve J (1999) Structure of the femoral neck in hip fracture: cortical bone loss in the inferoanterior to superioposterior axis. J Bone Miner Res, 14: 111–119.
  • 3. Boivin G, Meunier PJ (2003) The mineralization of bone tissue: a forgotten dimension in osteoporosis research. Osteoporos Int, 14: 19–24.
  • 4. Boivin G, Farlay D, Bala Y, Doublier A, Meunier PJ, Delmas PD (2009) Influence of remodeling on the mineralization of bone tissue. Osteoporos Int, 20: 1023–1026.
  • 5. Bonnaire F, Straßberger C, Kieb M, Bula P (2012) Osteoporotic fractures of the proximal femur: What’s new? Chirurg, 83: 882–91.
  • 6. Busse B, Hahn M, Soltau M, Zustin J, Puschel K, Duda GN, Amling M (2009) Increased calcium content and inhomogeneity of mineralization render bone toughness in osteoporosis: mineralization, morphology and biomechanics of human single trabeculae. Bone, 45: 1034–1043.
  • 7. Chai B, Tang X, Li H (1998) Ultrastructural evidence for vulnerability of hipregion to fracture in the aged. ChinMed J, 111: 823–828.
  • 8. Chavassieux P, Seeman E, Delmas PD (2007) Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease. Endocr Rev, 28: 151–164.
  • 9. Currey JD (2002) Bones: structure and mechanics. Princeton University Press, Princeton, NJ.
  • 10. Duboeuf F, Jergas M, Schott AM, Wu CY, Glüer CC, Genant HK (1995) A comparison of bone densitometry measurements of the central skeleton in postmenopausal women with and without vertebral fracture. Br J Radiol, 68:747–753.
  • 11. Eckstein F, Milz S, Anetzberger H, Putz R (1998) Thickness of the subchondral mineralised tissue zone (SMZ) in normal male and female pathological human patellae. J Anat, 192: 81–90.
  • 12. Faibish D, Ott SM, Boskey AL (2006) Mineral changes in osteoporosis: a review. Clin Orthop Relat Res, 443: 28–38.
  • 13. Felsenberg D, Boonen S (2005) The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther, 27: 1–11.
  • 14. Fountos G, Yasumura S, Glaros D (1997) The skeletal calcium/phosphorus ratio: a new in vivo method of determination. Med Phys, 24: 1303–1310.
  • 15. Fratzl P, Gupta HS, Paschalis EP, Roschger P (2004) Structure and mechanical quality of the collagen-mineral nonocomposite in bone. J Mater Chem, 14: 2115–2123.
  • 16. Fratzl-Zelman N, Roschger P, Gourrier A, Weber M, Misof BM, Loveridge N, Reeve J, Klaushofer K, Fratzl P (2009) Combination of nanoindentation and quantitative backscattered electron imaging revealed altered bone material properties associated with femoral neck fragility. Calcif Tissue Int, 85: 335–343.
  • 17. Fratzl-Zelman N, Roschger P, Misof BM, Nawrot-Wawrzyniak K, Potter-Lang S, Muschitz C, Resch H, Klaushofer K, Zwettler E (2011) Fragility fractures in men with idiopathic osteoporosis are associated with undermineralization of the bone matrix without evidence of increased bone turnover. Calcif Tissue Int, 88: 378–387.
  • 18. Hadjipanteli A, Kourkoumelis N, Fromme P, Olivo A, Huang J, Speller R (2013) A new technique for the assessment of the 3D spatial distribution of the calcium/phosphorus ratio in bone apatite. Physiol Meas, 34: 1399–1410.
  • 19. Hordon LD, Raısı M, Aaron JE, Paxton SK, Beneton M and Kanıs JA (2000) Trabecular Architecture in women and men of similar bone mass with and without vertebral fracture: I. Two-Dimensional Histology. Bone, 27: 271–276.
  • 20. Kim JW, Jeon YJ, Baek DH, Kim TN, Chang JS (2014) Percentage of the population at high risk of osteoporotic fracture in South Korea: analysis of the 2010 Fifth Korean National Health and Nutrition Examination survey data. Osteoporos Int, 25: 1313–1319.
  • 21. Lambert JK, Zaidi M, and Mechanick JI (2011) Male osteoporosis: epidemiology and the pathogenesis of aging bones. Current Osteoporosis Reports, 9: 229–236.
  • 22. Leszczyński B, Skrzat J, Kozerska M, Wróbel A, Walocha J (2014) Three dimensional visualisation and morphometry of bone samples studied in microcomputed tomography (micro-CT). Folia Morphol, 73: 422–428.
  • 23. Li B, Aspden RM (1997) Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarhritis. J Bone Miner Res, 12: 641–651.
  • 24. Li B, Marshall D, Roe M, Aspden RM (1999) The electron microscope of the subchondral bone plate in the human femoral head in osteoarthritis and osteoporosis. J Anat, 195: 101–110.
  • 25. Loveridge N, Power J, Reeve J, Boyde A (2004) Bonemineralization density and femoral neck fragility. Bone, 35: 929–941.
  • 26. Lozo P, Krpan D, Krvavica A, Vukelić Baturić T, Fistonić I, Kusec V (2004) Bone histology in postmenopausal osteoporosis-variations in cellular activity. Acta Med Croatica, 58: 5–11.
  • 27. Maharlouei N, Khodayari M, Forouzan F, Rezaianzadeh A, Lankarani KB (2014) The incidence rate of hip fracture in Shiraz, Iran during 2008–2010. Arch Osteoporos, 9: 165–169.
  • 28. Petersen MB, Jorgensen HL, Hansen K, Duus BR (2006) Factors affecting postoperative mortality of patients with displaced femoral neck fracture. Injury, 37: 705–711.
  • 29. Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet, 377: 1276–1287.
  • 30. Rizzoli R (2010) Microarchitecture in focus. Osteoporos Int, 21: 403–406.
  • 31. Roschger P, Gupta HS, Berzlanovich A, Ittner G, Dempster DW, Fratzl P, Cosman F, Parisien M, Lindsay R, Nieves JW (2003) Constant mineralization density distribution in cancellous human bone. Bone, 32: 316–323.
  • 32. Roschger P, Paschalis EP, Fratzl P, Klaushofer K (2008) Bone mineralization density distribution in health and disease. Bone, 42: 456–466.
  • 33. Schüpbach P, Glauser R, Rocci A, Martignoni M, Sennerby L, Lundgren AK, Gottlow J (2005) The human bone–oxidized titanium implant interface: A light microscopic, scanning electron microscopic, back-scatter scanning electron microscopic, and energy-dispersive X-ray study of clinically retrieved dental implants. Clin Implant Dent Relat Res, 7: 36–43.
  • 34. Seeman E, Tsalamandris C, Formica C, Hopper JL, McKay J (1994) Reduced femoral neck bone density in the daughters of women with hip fractures: the role of lowpeak bone density in the pathogenesis of osteoporosis. J Bone Miner Res, 9: 739–743.
  • 35. Seeman E, Delmas PD (2006) Bone quality: the material and structural basis of bone strength and fragility. N Engl J Med, 354: 2250–2261.
  • 36. Senol Y, Akdeniz M (2010) Yaslılık ve Koruyucu Tıp. GeroFam, 1: 49–68.
  • 37. Schuit SCE, van der Klift M, Weel AEAM, de Laet CEDH, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JPTM, Pols HAP (2004) Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam study. Bone, 34: 195–202.
  • 38. Shapiro R, Heaney RP (2003) Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency. Bone, 32: 532–540.
  • 39. Shea JE, Vajda EG, Bloebaum RD (2001) Evidence of a hyper mineralised calcified fibrocartilage on the human femoral neck and lesser trochanter. J Anat, 198: 153–162.
  • 40. Szulc P, Munoz F, Duboeuf F, Marchand F, Delmas PD (2005) Bone mineral density predicts osteoporotic fractures in elderly men: the MINOS study. Osteoporos Int, 16: 1184–1192.
  • 41. Teegarden D, Lyle RM, McCabe GP, McCabe LD, Proulx WR, Michon K, Knight AP, Johnston CC, Weaver CM (1998) Dietary calcium, protein, and phosphorus are related to bone mineral density and content in young women. Am J Clin Nutr, 68: 749–54.
  • 42. Tuzun S, Eskiyurt N, Akarirmak U, Saridogan M, Senocak M, Johansson H, Kanis JA (2012) Incidence of hip fracture and prevalence of osteoporosis in Turkey: the Fracture study. Osteoporos Int, 23: 949–955.
  • 43. Tzaphlidou M, Speller R, Royle G, Griffiths J, Olivo A, Pani S, Longo R (2005) High resolution Ca/P maps of bone architecture in 3D synchrotron radiation microtomographic images. Appl Radiat Isot, 62: 569–575.
  • 44. Wawrzyniak A, Horst-Sikorska W (2008) Senile osteoporosis. Pol Arch Med Wewn, 118: 59–62.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-e10d3f82-9788-4b11-af43-8131b3ae7762
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.