Relaxin-3 innervation of the intergeniculate leaflet in the rat

• Autorzy: Blasiak A. , Blasiak T. , Czubak W. , Gundlach A. , Lewandowski M.
• Języki publikacji: EN

Abstrakty

EN

The intergeniculate leafl et of the thalamus (IGL), a subdivision of the lateral geniculate body, is a component of the biological clock, responsible for, amongst other things, the synchronizing effect of timed caloric restriction on locomotor activity in rodents. The IGL has a distinct functional and anatomical profi le amongst thalamic nuclei, including strong peptidergic inputs (e.g. orexin and PACAP). Recently a dense network of terminals immunoreactive for relaxin-3 (RLX3) was identifi ed in IGL. RLX3 is a newly discovered neuropeptide expressed in high levels in brain. The physiological actions of RLX3 are largely unknown, but recent studies have suggested infl uences on feeding, stress responses and spatial memory. The majority of RLX3 neurons are located in the nucleus incertus (NI), but prior anatomical studies have excluded the NI as a source of the RLX3 in the IGL. In this study, we used neural tract-tracing and immunohistochemistry to demonstrate that the major source of RLX3 fi bers within IGL originates from RLX3 neuron populations in the periventricular- and periaqueductal gray. Furthermore, some of these IGL-projecting RLX3 neurons express corticotropin-releasing factor receptors, indicating that the RLX3 innervation may transmit stress-related responses to the IGL. Since stress is one of the non-photic factors capable of synchronizing behavioural rhythmicity, our data suggest that RLX3 might be another key element in the complex mammalian circadian system.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.362

Twórcy

autor

Blasiak A.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland

autor

Blasiak T.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland

autor

Czubak W.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland

autor

Gundlach A.

• Florey Neuroscience Institutes, The University of Melbourne, Melbourne, Australia

autor

Lewandowski M.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland