MiRNA-21, miRNA-10b, and miRNA-34a expression in canine mammary gland neoplasms

• Autorzy: Losiewicz K. , Chmielewska-Krzesinska M. , Socha P. , Jakimiuk A. , Wasowicz K.
• Języki publikacji: EN

Abstrakty

EN

The expression of miRNA-21, miRNA-l0b, and miRNA-34a in malignant and benign tumours and non-neoplastic lesions in canine mammary gland, using real-time PCR with TaqMan probes was determined. The expression in normal tissues was compared to neoplastic and non-neoplastic lesions using one-way ANOVA test. Significant changes in miRNA expression in neoplastic tissues, as compared to normal ones, were demonstrated. In all neoplastic tissues, the miRNA-21 expression increased while in non-neoplastic lesions slightly decreased in comparison to normal ones. MiRNA-l0b expression in malignant and benign tumours increased in comparison to normal tissues and non-neoplastic lesions. MiRNA-34a expression profile in neoplastic and non-neoplastic tissues differed from other examined miRNAs (miRNA-21 and miRNA-l0b). In all samples miRNA-34a expression level decreased in comparison to normal tissues.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2014
• Tom: 58
• Numer: 3
• Opis fizyczny: p.447-451,fig.,ref.

Twórcy

autor

Losiewicz K.

• Department of Pathophysiology, Forensic Veterinary and Administration, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland

autor

Chmielewska-Krzesinska M.

• Department of Pathophysiology, Forensic Veterinary and Administration, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland
• Department of Animal Anatomy, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland

autor

Socha P.

• Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland

autor

Jakimiuk A.

• Department of Pathophysiology, Forensic Veterinary and Administration, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland

autor

Wasowicz K.

• Department of Pathophysiology, Forensic Veterinary and Administration, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland

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Identyfikatory

DOI

10.2478/bvip-2014-0068