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2016 | 19 | 4 |

Tytuł artykułu

Cholesterol Deficiency - new genetic defect transmitted to Polish Holstein-Friesian cattle

Autorzy

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the study was to find out whether carriers of new genetic defect Cholesterol Deficiency (CD) occur in the population of Polish Holstein-Friesian bulls. Twenty seven bulls were included in the analysis. Bulls were selected as having in the pedigree known carrier of CD (Maughlin Storm CANM000005457798). All bulls were diagnosed by the test described by Menzi et al. (2016) by using allele-specific PCR. Among 27 bulls, 9 new CD carriers were found. Our results show that causal mutation for CD is already transmitted to Polish Holstein-Friesian cattle. The results are sufficient ground to take practical action in order to avoid further spreading of mutation causing CD.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

19

Numer

4

Opis fizyczny

p.885-887,fig.,ref.

Twórcy

autor
  • University of Warmia and Mazury, Department of Animal Genetics, Oczapowskiego 5, 10-719 Olsztyn, Poland
autor
  • University of Warmia and Mazury, Department of Animal Genetics, Oczapowskiego 5, 10-719 Olsztyn, Poland

Bibliografia

  • Czarnik U, Grzybowski G, Kamiński S, Prusak B, Zabolewicz T (2007) Effectiveness of a program aimed at the elimination of BLAD-carrier bulls from the Polish Holstein-Friesian cattle. J Appl Genet 48: 375-377.
  • Gross JJ, Schwinn AC, Schmitz-Hsu F, Menzi F, Drögemüller C, Albrecht C, Bruckmaier RM (2016) Rapid Communication: Cholesterol deficiency-associated APOB mutation impacts lipid metabolism in Holstein calves and breeding bulls. J Anim Sci 94: 1761-1766.
  • Kipp S, Segelke D, Schierenbeck S (2015) A new Holstein haplotype affecting calf survival. Proceedings of the 2015 Interbull Meeting, July 09-12, 2015, Orlando, Florida, USA. Interbull Bulletin 49: 49-53.
  • Menzi F, Besuchet-Schmutz N, Fragniére M, Hofstetter S, Jagannathan V, Mock T, Raemy A, Studer E, Mehinagic K, Regenscheit N, Meylan M, Schmitz-Hsu F, Drögemüller C (2016) A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle. Anim Genet 47(2): 253-257.
  • OMIA Database 001965-9913. Online Mendelian Inheritance of Animals. http://omia.angis.org.au/OMIA001965
  • Ruść A, Hering D, Puckowska P, Barcewicz M, Kaminski S (2013) Screening of Polish Holstein-Friesian bulls towards eradication of Complex Vertebral Malformation (CVM) carriers. Pol J Vet Sci 16: 579-581.
  • Schütz E, Wehrhahn C, Wanjek M, Bortfeld R, Wemheuer WE, Beck J, Brenig B (2016) The Holstein Friesian Lethal Haplotype 5 (HH5) Results from a Complete Deletion of TF B1M and Cholesterol Deficiency (CDH) from an ERV-(LTR) Insertion into the Coding Region of APOB. PLoS One 11: e0154602.
  • VanRaden P, Null D (2015) Holstein haplotype for cholesterol deficiency (HCD). Website of US Council of Dairy Cattle Breeding. https://www.cdcb.us/reference/changes/HCD–inheritance.pdf
  • Young SG, Northey ST, McCarthy BJ (1988) Low plasma cholesterol levels caused by a short deletion in the apolipoprotein B gene. Science 241: 591-593.

Typ dokumentu

Bibliografia

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