PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2014 | 17 | 1 |

Tytuł artykułu

The effect of dietary L-arginine intake on the level of antibody titer, the relative organ weight and colon motility in broilers

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
This study was carried out to determine the effect of L-arginine (L-Arg) levels in diet at the starter, grower and finisher phases on immune response, organ development, nitric oxide (NO) metabolism and colon motility in broilers. A total of 500 one-day-old Ross-308 broiler chickens of mixed sex were separated into one Arg-deficient group and four experimental groups. Each group was then divided into five subgroups of 20 birds each. Arginine deficient group for all phases was fed a basal diet which contained 10% less L-Arg than optimum Arg requirement recommended by the breeder. Experimental groups were fed a basal diet supplemented with L-Arg which was progressively 10% increased in groups. Thus, the diet contained 90, 100, 110, 120 and 130% of optimum Arg requirement for each phases in groups, respectively. The highest serum infectious bursal disease antibody titer (IBD) was observed in the experimental group which was fed the diet containing 110% L-Arg at grower phase (P<0.05), whereas Newcastle disease antibody titer did not differ between groups. The relative weight of spleen increased in groups which were fed the diet containing 120 and 130% L-Arg at starter phase as compared to Arg-deficient group (P<0.05). The group which was fed the diet containing 110% L-Arg showed highest relative weight of bursa Fabricii at grower (P<0.05) and finisher (P<0.01) phases. It was observed that serum nitric oxide (NO) concentration decreased in Arg-deficient group (P<0.05). The amplitude of spontaneous colon contractility did not differ between groups at the end of all three phases. However, the frequency of spontaneous colon contractility in the Arg deficient group was higher at starter (P<0.05), grower (P<0.01) and finisher (P<0.05) phases.These results suggest that the supplementation of L-Arg at higher level than optimum Arg requirement in broiler diet has minimal effect on parameters investigated in the study. However, L-Arg-deficiency may negatively affect immune response and the motility of gastrointestinal system due to disruption of NO metabolism at three phases.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

17

Numer

1

Opis fizyczny

p.113-121,fig.,ref.

Twórcy

autor
  • Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
autor
  • Department of Anatomy, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
autor
  • Department of Physiology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
autor
  • Department of Physiology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey

Bibliografia

  • Abdulkalykova S, Ruiz-Feria CA (2006) Arginine and vitamin E improve the cellular and humoral immune response of broiler chickens. Int J Poult Sci 5: 121-127.
  • Allen PC, Fetterer RH (2000) Effect of Eimeria acervulina infections on plasma L-arginine. Poult Sci 79: 1414-1417.
  • AOAC (2000) Official Methods of Analysis of the Association of Official Analytical Chemists. 17th ed., Maryland, USA.
  • Bani D, Baccari MC, Quattrone S, Nistri S, Calamai F, Bigazzi M, Bani Sacchi T (2002) Relaxin depresses small bowel motility through a nitric oxide-mediated mechanism. Studies in mice. Biol Reprod 66: 778-784.
  • Barbul A, Sisto DA, Wasserkrug HL, Efron G (1981) Arginine stimulates lymphocyte immune response in healthy human beings. Surgery 90: 244-251.
  • Boeckxstaens GE, Pelckmans PA, Bogers JJ, Bult H, De Man JG, Oosterbosch L, Herman AG, Van Maercke YM (1991) Release of nitric oxide upon stimulation of nonadrenergic noncholinergic nerves in the rat gastric fundus. J Pharmacol Exp Ther 256: 441-447.
  • Broiler Nutrition Specifications (2007) Ross 308 broiler nutrition specifications. Aviagen, Newbridge, Midlothian, Scotland. http://en.aviagen.com/ross-308/
  • Bulbul A, Bulbul T, Sevimli A O Yilmaz O (2013) The effect of dietary supplementation of nitric oxide donor and inhibitor on nNOS expression in and motility of the small intestine of broilers. Biotech Histochem 88: 258-266.
  • Bulbul A, Yagcy A, Altunbas K, Sevimli A, Celik HA, Karadeniz A, Akdag E (2007) The role of nitric oxide in the effects of ovarian steroids on spontaneous myometrial contractility in rats. Theriogenology 68: 1156-1168.
  • Bult H, Boeckxstaens GE, Pelckmans PA, Jordaens FH, Van Maercke YM, Herman AG (1990) Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature 345: 346-347.
  • Cengiz O, Kuçukersan S (2010) Effects of graded contents of arginin supplementation on growth performance, haematological parameters and immune system in broilers. Revue Med Vet 161: 409-417.
  • Corzo A, Moran Jr ET, Hoehler D (2003) Arginine need of heavy broiler males: applying the ideal protein concept. Poult Sci 82: 402-407.
  • Dumonceaux G, Harrison GJ (1994) Hematology. In: Ritchie BW, Harrison GJ, Harrison LR (eds) Avian medicine: principles and application. Wingers Publishing Inc., Lake Worth, Florida, pp 1031-1035.
  • Evoy D, Lieberman MD, Fahey TJ, Daly JM (1998) Immunonutrition: the role of arginine. Nutrition 14: 611-617.
  • Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci 84: 9265-9269.
  • Izzo AA, Mascolo N, Capasso F (1998) Nitric oxide as a modulator of intestinal water and electrolyte transport. Dig Dis Sci 43: 1605-1620.
  • Kidd MT, Peebles ED, Whitmarsh SK, Yeatman JB, Wideman RF (2001) Growth and immunity of broiler chicks as affected by dietary arginine. Poult Sci 80: 1535-1542.
  • Konashi S, Takahashi K, Akiba Y (2000) Effects of dietary essential amino acid deficiencies on immunological variables in broiler chickens. Br J Nutr 83: 449-456.
  • Kwak H, Austic RE, Dietert RR (1999) Influence of dietary arginine concentration on lymphoid organ growth in chickens. Poult Sci 78: 1536-1541.
  • Lee JE, Austic RE, Naqi SA, Golemboski KA, Dietert RR (2002) Dietary arginine intake alters avian leukocyte population distribution during infectious bronchitis challenge. Poult Sci 81: 793-798.
  • Li CG, Rand MJ (1990) Nitric oxide and vasoactive intestinal polypeptide mediate non- adrenergic, non-cholinergic inhibitory transmission to smooth muscle of the rat gastric fundus. Eur J Pharmacol 191: 303-309.
  • McCall TB, Feelisch M, Palmer RM, Moncada S (1991) Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. Br J Pharmacol 102: 234-238.
  • Miranda KM, Espey MG, Wink DA (2001) A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5: 62-71.
  • Rodeberg DA, Chaet MS, Bass RC, Arkovitz MS, Garcia VF (1995) Nitric oxide: an overview. Am J Surg 170: 292-303.
  • Shah S, Nathan L, Singh R, Fu YS, Chaudhuri G (2001) E2 and not P4 increases NO release from NANC nerves of the gastrointestinal tract: implications in pregnancy. Am J Physiol Regul Integr Comp Physiol 280: 1546-1554.
  • Srinongkote S, Smriga M, Toride Y (2004) Diet supplied with L-lysine and L-arginine during chronic stress of high stock density normalizes growth of broilers. Anim Sci J 75: 339-343.
  • Su CL, Austic RE (1998) The utilization of dipeptides containing L-arginine by chicken macrophages. Poult Sci 77: 1852-1857.
  • Sung YJ, Hotchkiss JH, Austic RE, Dietert RR (1991) L-arginine- dependent production of a reactive nitrogen intermediate by macrophages of a uricotelic species. J Leukoc Biol 50: 49-56.
  • Tachibana K, Mukai K, Hiraoka I, Moriguchi S, Takama S, Kishino Y (1985) Evaluation of the effect of arginine- enriched amino acid solution on tumor growth. JPEN J 9: 428-434.
  • Toda N, Baba, H, Okamura T (1990) Role of nitric oxide in non-adrenergic, non-cholinergic nerve-mediated relaxation in dog duodenal longitudinal muscle strips. Jpn J Pharmacol 53: 281-284.
  • Webel DM, Johnson RW, Baker DH (1998) Lipopolysaccharide- induced reductions in body weight gain and feed intake do not reduce the efficiency of arginine utilization for whole-body protein accretion in the chick. Poult Sci 77: 1893-1898.
  • Wright CE, Ress DD, Moncada S (1992) Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 26: 48-57.
  • Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C (1992) Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256: 225-228.
  • Zhao JP, Jiao HC, Song ZG, Lin H (2009) Effects of L-arginine supplementation on glucose and nitric oxide (NO) levels and activity of NO synthase in corticosterone- challenged broiler chickens (Gallus gallus). Comp Biochem Physiol C Toxicol Pharmacol 150: 474-80.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-dd9acc91-1aaa-49a3-b7e3-c625cd17bffe
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.