Reinforcement of en early-LTP in the hipocampall CAI by stimulation of the ventral tegmental area in freely moving rats

• Autorzy: Scherf T. , Frey J. , Frey S.
• Języki publikacji: EN

Abstrakty

EN

It has been shown that the prolonged maintenance of hippocampal long-term potentiation (LTP) requires heterosynaptic events during its induction. The ventral tegmental area (VTA), a modulatory input to the CA1 region is a heterogeneous group of dopaminergic cells and a major component of the mesolimbic dopamine system. We used a method which allowed us to simultaneously record both, the fi eld-EPSP and the population spike (POP) in the hippocampal CA1 in freely moving rats by stimulation of the contralateral CA3. We could show that an early-LTP in the CA1 region can be reinforced into a longer-lasting form by high-frequency stimulation of the VTA 15 min after its induction. This reinforcement of an early-LTP in CA1 was dependent on dopaminergic receptor activation and was also dependent on protein synthesis. We have now extended our studies and could show that high-frequency stimulation of the VTA alone, i.e. without LTP-induction in CA1, caused a delayed-onset potentiation for the recorded fi eld-EPSP and POP in the CA1 region in response to test stimulation of the contralateral CA3. This delayedonset potentiation was dependent on the synergistic activation of both the glutamatergic and the dopaminergic receptor activation, because paused glutamatergic test stimulation abolished this potentiation.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.333

Twórcy

autor

Scherf T.

• Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany

autor

Frey J.

• Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany

autor

Frey S.

• Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany