Antiprotozoal effect of steroid hormone 20-hydroxyecdysone in giardiosis patients

• Autorzy: Toychiev A. , Kerimov F. , Islamova J. , Shaislamova M. , Mirzakhmedov M. , Davis N. , Syrov V. , Osipova S.
• Języki publikacji: EN

Abstrakty

EN

The World Health Organization reports that approximately 200 million people are infected with Giardia (G.) lamblia worldwide. Taking into account the emergence of resistance and the high toxicity of conventional drugs, research into new strategies to fight against G. lamblia is increasing. The aim of the study was to assess the antiprotozoal activity of 20-hydroxyecdysone in water sports athletes with giardiosis. A randomized, double-blinded, placebocontrolled clinical study was conducted. Seventy-six athletes with G. lamblia infection participated in the study and were divided into 20-hydroxyecdysone, metronidazole and placebo groups. Clinical, parasitological, haematological and biochemical analyses were performed. Positive results for antiprotozoal therapy were revealed in the 20-hydroxyecdysone and metronidazole groups. After therapy, elimination of G. lamblia was observed in 100.0% of the athletes included in the 20-hydroxyecdysone group. However, G. lamblia was resistant to metronidazole in 4.0% of athletes included in the metronidazole group. A positive clinical response to the therapy occurred in the 20-hydroxyecdysone and metronidazole groups. Our study reveals high antiprotozoal activity of 20-hydroxyecdysone against G. lamblia. Further clinical studies are necessary to evaluate the antiprotozoal efficacy of 20-hydroxyecdysone.

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2022
• Tom: 68
• Numer: 3
• Opis fizyczny: p.605-615,fig.,ref.

Twórcy

autor

Toychiev A.

• Department of Immunology of Parasitic and Fungal Diseases, Republican Specialized Research and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan

autor

Kerimov F.

• Department of Theory and Methodology of Physical Culture and Sports, Uzbek State University of Physical Education and Sport, Tashkent, Uzbekistan

autor

Islamova J.

• Department of Pharmacology, Institute of the Chemistry of Plant Substances named acad. S. Yu. Yunusov, Tashkent, Uzbekistan

autor

Shaislamova M.

• Department of Immunology of Parasitic and Fungal Diseases, Republican Specialized Research and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan

autor

Mirzakhmedov M.

• Department of General Surgery, Tashkent Medical Academy, Tashkent, Uzbekistan

autor

Davis N.

• Department of Immunology of Parasitic and Fungal Diseases, Republican Specialized Research and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan

autor

Syrov V.

• Department of Pharmacology, Institute of the Chemistry of Plant Substances named acad. S. Yu. Yunusov, Tashkent, Uzbekistan

autor

Osipova S.

• Department of Immunology of Parasitic and Fungal Diseases, Republican Specialized Research and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan

Identyfikatory

DOI

10.17420/ap6803.467