Bacterial putative metacaspase structure from Geobacter sulfureducens as a template for homology modelling of type II Triticum aestivum metacaspase (TaeMCAII)

• Autorzy: Dudkiewicz M. Z. , Piszczek E.
• Języki publikacji: EN

Abstrakty

EN

 Metacaspases, cysteine proteases belonging to the peptidase C14 family, are suspected of being involved in the programmed cell death of plants, although their sequences and substrate specificity differ from those of animal caspases. At present, the knowledge on the metacaspase reaction mechanism is based only on biochemical data and homology models constructed on caspase templates. Here we propose a novel template for metacaspase modeling and demonstrate important advantages in comparison to the conventionally used caspase templates. We also point out the connection between plant and bacterial metacaspases, underlining the prokaryotic roots of Programmed Cell Death (PCD).

Słowa kluczowe

EN

apoptosis; metacaspase; Geobacter sulfureducens; homology modelling; plant; Triticum aestivum; cell cycle regulation; autophagy; caspase

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 3
• Opis fizyczny: p.401-406,fig.,ref.

Twórcy

autor

Dudkiewicz M. Z.

• Department of Biometrics and Bioinformatics, Faculty of Agriculture and Biology, Warsaw University of Life Sciences - SGGW, Warsaw, Poland

autor

Piszczek E.

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