Effect of dopamine receptor stimulation on voltage-dependent fast-inactivating Na plus currents in medial prefrontal cortex (mPFC) pyramidal neurons in adult rats

• Autorzy: Szulczyk B. , Ksiazek A. , Ladno W. , Szulczyk P.
• Języki publikacji: EN

Abstrakty

EN

Impaired working memory is a common feature of neuropsychiatry disorders. It is dependent on control of the medial prefrontal cortex (mPFC) neurons by dopamine. The purpose of this study was to test the effects of a D1/5-type dopamine receptor agonist (SKF 38393, 10 ^M) on the membrane potential and on voltage-dependent fast-inactivating Na+ currents in mPFC pyramidal neurons obtained from adult (9-week-old) rats. Treatment of the pyramidal neurons with SKF 38393 did not affect the membrane potential recorded with the perforated-patch method. When recordings were performed in cell- attached configuration, the application of SKF 38393 did not change the Na+ current amplitude and shifted the current- voltage relationship of the Na+ currents towards hyperpolarisation, thus resulting in an increase of the current amplitudes in response to suprathreshold depolarisations. Pretreatment of the cells with a D1/5 receptor antagonist (SCH 23390, 10 ^M) abolished the effect of the D1/5-type receptors on Na+ currents. The effect of the D1/5 agonist was replicated by treating the cells with a membrane-permeable analogue, cAMP (8-bromo-cAMP, 100 ^M), and the effect was blocked by treating the cells with a protein kinase A inhibitor, (H-89, 2 ^M). In recordings performed from mechanically and enzymatically dispersed pyramidal neurons in the whole-cell configuration, when the cell interior was dialysed with pipette solution, application of the D1/5 agonist decreased the Na+ current amplitude without changing the current-voltage relationship. We conclude that in the mPFC pyramidal neurons in slices with an intact intracellular environment (recordings in the cell-attached configuration), the activation of D1/5 dopamine receptors increases the fast-inactivating Na+ current availability in response to suprathreshold depolarisations. The maximum Na+ current amplitude was not changed. A cAMP/protein kinase A pathway was responsible for the signal transduction from the D1/5 dopamine receptors to the Na+ channels.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2012
• Tom: 72
• Numer: 4
• Opis fizyczny: p.351-364,fig.,ref.

Twórcy

autor

Szulczyk B.

• Department of Psychology and Pathophysiology, Medical University of Warsaw, Warsaw, Poland

autor

Ksiazek A.

• Department of Psychology and Pathophysiology, Medical University of Warsaw, Warsaw, Poland

autor

Ladno W.

• Department of Psychology and Pathophysiology, Medical University of Warsaw, Warsaw, Poland

autor

Szulczyk P.

• Department of Psychology and Pathophysiology, Medical University of Warsaw, Warsaw, Poland

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