Association of hemophagocytic lymphohistiocytosis with kidney lesions in acute African swine fever virus infection

• Autorzy: Karalyan N.Yu. , Tatoyan M.R. , Semerjyan A.B. , Nersisyan N.H. , Semerjyan Z.B. , Hakobyan L.H. , Karalyan Z.A.
• Języki publikacji: EN

Abstrakty

EN

Glomerulonephritis due to African swine fever (ASF) is well documented. However, there is absence of good understanding of mechanisms involved in the development of pathology development. This study examines glomerulonephritis in association with acute infection induced by II genotype (Georgia 2007) of ASF virus. Taken together, the results of urinary analysis and the renal histological analysis led to the diagnosis of diffuse endocapillary proliferative glomerulonephritis with severe tubular injury associated with acute ASF (Georgia 2007). According to the pathogenesis, we have found that the diffuse endocapillary proliferative glomerulonephritis associated with the acute ASF develops with a delay of one to two days compared to development of hemophagocytic lymphohistiocytosis. The diagnosis of endocapillary proliferative glomerulonephritis confirms the characteristic of pathological changes in the composition of urine and urine sediment. The development of acute proliferative glomerulonephritis begins at 3 dpi, and finished at 4–6 dpi with the development of tubular necrosis. Our study demonstrates local macrophage proliferation. Local proliferation may be an important mechanism for amplifying macrophage-mediated renal injury. We have shown that the development of diffuse acute proliferative glomerulonephritis during ASF does not coincide with the presence of the virus in the blood or kidney tissues, but coincides with the developmental of ASFV derived hemophagocytic lyphohistiocytosis. The development of hemophagocytic lymphonocytosis also begins at least at 2–3 dpi and continues up to the terminal stage of the disease.

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2018
• Tom: 64
• Numer: 4
• Opis fizyczny: p343-350,fig.,ref.

Twórcy

autor

Karalyan N.Yu.

• Department of Pathological Anatomy and Clinical Morphology, Armenia Yerevan State Medical University, 2 Koryun St., Yerevan 0025, Armenia

autor

Tatoyan M.R.

• Department of Cytology, Histology and Embryology, Armenia Yerevan State Medical University, 2 Koryun St., Yerevan 0025, Armenia

autor

Semerjyan A.B.

• Department of Medical Biology and Parasitology, Armenia Yerevan State Medical University, 2 Koryun St., Yerevan 0025, Armenia

autor

Nersisyan N.H.

• Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., Yerevan 0014, Armenia

autor

Semerjyan Z.B.

• Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., Yerevan 0014, Armenia

autor

Hakobyan L.H.

• Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., Yerevan 0014, Armenia

autor

Karalyan Z.A.

• Department of Medical Biology and Parasitology, Armenia Yerevan State Medical University, 2 Koryun St., Yerevan 0025, Armenia
• Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., Yerevan 0014, Armenia
• Department of Bioengineering, Bioinformatics and Molecular Biology, Russian-Armenian (Slavonic) University, 123 Hovsep Emin St., Yerevan 0051, Armenia

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Identyfikatory

DOI

10.17420/ap6404.170