Genetic correlation between analgesia, metabolism and thermoregulation in a cross between mouse lines with high and low pain sensitivity

• Autorzy: Sacharczuk M. , Fedorowicz K. , Konarzewski M. , Lapo I. , Lesniak A. , Lipkowski A.W. , Ragan A. , Jaszczak K. , Sadowski B.
• Języki publikacji: EN

Abstrakty

EN

Exposure of an animal to stressful stimuli elicits a transient decrease in pain sensitivity, which often affects thermoregulatory mechanisms in the threatened organism. Briefly, we found that stress-induced analgesia (SIA) is inversely related to PMR (peak metabolic rate) and thermogenic capacity. This relationship was strong enough to permit the claim of an existence of a negative genetic correlation between SIA and PMR as well as thermogenesis. In the present study we performed a genome-wide quantitative trait locus (QTL) analysis in our mouse model established from outbred parental lines divergently selected for 60 generations for high- (HA line) or low- (LA line) swim stress-induced analgesia (SSIA) elicited by 3-min swim in 20°C water. The F2 population of 267 mice was used for the QTL analysis with 40 microsatellite markers distributed across the first five chromosomes. The analysis revealed significant QTLs SIA, for peak metabolism rate (PMR) and for hypothermia (Hyp). Some of these QTLs map to regions of known gene mutations influencing SIA, PMR and Hyp traits, moreover they map to regions of previously described QTLs and candidate genes. Apart from QTLs affecting single traits we identified QTLs common for examined traits (SIA-PMR-Hyp), (SIA-PMR), (SIA-Hyp) and (PMR-SIA) parameters, which explain phenotypic correlations between these traits.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: 1
• Opis fizyczny: p.163-164

Twórcy

autor

Sacharczuk M.

• Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland

autor

Fedorowicz K.

• Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland

autor

Konarzewski M.

• Department of Animal Ecology, University of Bialystok, Bialystok, Poland

autor

Lapo I.

• Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland

autor

Lesniak A.

• Neuropeptide Laboratory, Mossakowski Medical Research Centre, Polish Academy of Sciences,Warsaw, Poland

autor

Lipkowski A.W.

• Neuropeptide Laboratory, Mossakowski Medical Research Centre, Polish Academy of Sciences,Warsaw, Poland

autor

Ragan A.

• Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland

autor

Jaszczak K.

• Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland

autor

Sadowski B.

• Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland