Occlusion of retinal capillaries caused by glial cell proliferation in chronic ocular inflammation

• Autorzy: Bianchi E. , Ripandelli G. , Feher J. , Plateroti A.M. , Plateroti R. , Kovacs I. , Plateroti P. , Taurone S. , Artico M.
• Języki publikacji: EN

Abstrakty

EN

The inner blood-retinal barrier is a gliovascular unit in which glial cells surround capillary endothelial cells and regulate retinal capillaries by paracrine interactions. During chronic ocular inflammation, microvascular complications can give rise to vascular proliferative lesions, which compromise visual acuity. This pathologic remodelling caused by proliferating Müller cells determines occlusion of retinal capillaries. The aim of the present study was to identify qualitative and quantitative alterations in the retinal capillaries in patients with post-traumatic chronic ocular inflammation or post-thrombotic vascular glaucoma. Moreover, we investigated the potential role of vascular endothelial growth factor (VEGF) and pro-inflammatory cytokines in retinal inflammation. Our electron microscopy findings demonstrated that during chronic ocular inflammation, thickening of the basement membrane, loss of pericytes and endothelial cells and proliferation of Müller cells occur with irreversible occlusion of retinal capillaries. Angiogenesis takes place as part of a regenerative reaction that results in fibrosis. We believe that VEGF and pro-inflammatory cytokines may be potential therapeutic targets in the treatment of this disease although further studies are required to confirm these findings. (Folia Morphol 2015; 74, 1: 33–41)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2015
• Tom: 74
• Numer: 1
• Opis fizyczny: p.33-41,fig.,ref.

Twórcy

autor

Bianchi E.

• Department of Sensory Organs, Sapienza University of Rome, V.le del Policlinico 155, 00161 Rome, Italy

autor

Ripandelli G.

• Bietti Eye Foundation, Rome, Italy

autor

Feher J.

• Department of Sensory Organs, Sapienza University of Rome, Italy
• Ophthalmic Neuroscience Program, Nutripharma Hungaria Ltd., Budapest, Hungary

autor

Plateroti A.M.

• Department of Sensory Organs, Sapienza University of Rome, Italy

autor

Plateroti R.

• Department of Sensory Organs, Sapienza University of Rome, Italy

autor

Kovacs I.

• Department of Ophthalmology, Semmelweiss University of Budapest, Hungary

autor

Plateroti P.

• Department of Sensory Organs, Sapienza University of Rome, Italy

autor

Taurone S.

• Department of Sensory Organs, Sapienza University of Rome, Italy

autor

Artico M.

• Department of Sensory Organs, Sapienza University of Rome, Italy

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Identyfikatory

DOI

10.5603/FM.2015.0006