Conjugated linoleic acid decreased serum triacyloglycerol and changed fatty acid composition in rat’s liver

• Autorzy: Kostogrys R. B. , Pisulewski P. M.
• Języki publikacji: EN

Abstrakty

EN

Extensive research have indicated that commercial conjugated linoleic acid (CLA), fed to laboratory animals, showed several health-related properties. The objective of this study was to assess the effect of CLA on serum lipid profile, plasma malondialdehyde and liver fatty acids profile in Wistar rats fed for 23 d. The experimental diets were: I-AIN-93G - control (C), II- AIN-93G diet + 1.0% CLA. The CLA oil contained 600 g CLA/kg, with equal representation of cis-9,trans-11 and trans-10,cis-12 CLA isomers. The experimental treatments had no effect on rats body weight, total cholesterol, HDL, LDL+VLDL and malondialdehyde. The triacylglycerol (TG) was significantly decreased after CLA supplementation. Liver weight, fat and histology were unchanged in CLA group. Liver cholesterol was insignificantly decreased in CLA diet. Dietary treatments had significant effects of on proportions of SFA and MUFA and PUFA in liver. In conclusion, CLA decreases serum TG. Additionally, liver fat composition were changed after CLA supplementation

Słowa kluczowe

EN

conjugated linoleic acid; serum; fatty acid composition; rat; liver; triacylglycerol; lipid profile; feed; animal feeding; laboratory animal

• Wydawca: -
• Czasopismo: Journal of Animal and Feed Sciences
• Rocznik: 2010
• Tom: 19
• Numer: 3
• Opis fizyczny: p.484-494,fig.,ref.

Twórcy

autor

Kostogrys R. B.

• Department of Human Nutrition, Faculty of Food Technology, Agricultural University of Krakow, Balicka 122, 30-149 Krakow, Poland

autor

Pisulewski P. M.

Bibliografia

• Arbonés-Mainar J.M., Navarro M.A., Acín S., Guzmán M.A., Arnal C., Surra J.C., Carnicer R., Roche H.M., Osada J., 2006. Trans-10, cis-12- and cis-9, trans-11-conjugated linoleic acid isomers selectively modify HDL-apolipoprotein composition in apolipoprotein E knockout mice. J. Nutr. 136, 353-359
• Belury M.A., 2002. Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J. Nutr. 132, 2995-2998
• Czauderna M., Kowalczyk J., Krajewska K.A., Rozbicka A.J., Michalski J.P., 2009. Dietary selenite and conjugated linoleic acid isomers influence fatty acid concentrations in the liver and femoral muscles of rats. J. Anim. Feed Sci. 18, 3, 564-581
• Czauderna M., Kowalczyk J., Niedźwiedzka K.M., Wąsowska I., Pastuszewska B., Bulska E., Ruszczyńska A., 2004. Liver and body mass gain, content of conjugated linoleic acid (CLA) isomers and other fatty acids in the liver of rats fed CLA isomers and selenium. J. Anim. Feed Sci. 13, 353-369
• Evans M., Brown J., McIntosh M., 2002. Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J. Nutr. Biochem. 13, 508-516
• Fernandez M.L., West K.L., 2005. Mechanisms by which dietary fatty acids modulate plasma lipids. J. Nutr. 135, 2075-2078
• Field C.J., Schley P.D., 2004. Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function: lessons from n-3 fatty acids. Amer. J. Clin. Nutr. 79, 1190S-1198S
• Franczyk-Żarów M., Kostogrys R.B., Szymczyk B., Jawień J., Gajda M., Cichocki T., Wojnar L., Chłopicki S., Pisulewski P.M., 2008. Functional effects of eggs, naturally enriched with conjugated linoleic acid (CLA), on the blood lipid profile, development of atherosclerosis and composition of atherosclerotic plaque in apolipoprotein E and low density lipoprotein receptor double-knockout mice (apoE/LDLR -/-). Brit. J. Nutr. 99, 49-58
• Griinari J.M., Bauman D.E., 1999. Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk in ruminants. In: M.P. Yurawecz, M.M. Mossoba, J.K.G. Kramer, M.W. Pariza, G.J. Nelson (Editors). Advances in Conjugated Linoleic Acid Research. AOCS Press. Champaign, IL, pp. 180-199
• Kiernan J.A., 1990. Histological and Histochemical Methods. Theory and Practice. 2nd Edition. Pergamon Press, Great Britain BPCC, Wheatons LTD. Exeter, pp. 413-421
• Korniluk K., Czauderna M., Kowalczyk J., Mieczkowska A., Taciak M., Leng Ľ., 2006. Influence of dietary conjugated linoleic acid isomers and selenium on growth, feed efficiency, and liver fatty acid profile in rats, J. Anim. Feed Sci. 15, 131-146
• Kritchevsky D., Tepper S.A., Wright S., Czarnecki S.K., 2002. Influence of graded levels of conjugated linoleic acid (CLA) on experimental atherosclerosis in rabbits. Nutr. Res. 22, 1275-1279
• Munday J.S., Thompson K.G., James K.A.C., 1999. Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model. Brit. J. Nutr. 81, 251-255
• Nicolosi R.J., Rogers E.J., Kritchevsky D., Scimeca J.A., Huth P.J., 1997. Dietary conjugated linoleic acid reduces plasma lipoproteins and early atherosclerosis in hypercholesterolemic hamsters. Artery 22, 266-277
• O’Shea M., Bassaganya-Riera J., Mohede I.C.M., 2004. Immunomodulatory properties of conjugated linoleic acid. Amer. J. Clin. Nutr. 79, 1199S-1206S
• Purushotham A., Shrode G.E., Wendel A.A., Liu L.F., Belury M.A., 2007. Conjugated linoleic acid does not reduce body fat but decreases hepatic steatosis in adult Wistar rats. J. Nutr. Biochem. 18, 676-684
• Reeves P.G., Nielsen F.H., Fahey G.C., 1993. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc Writing Committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123, 1939-1951
• Toomey S., Harhen B., Roche H.M., Fitzgerald D., Belton O., 2006. Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis 187, 40-49
• Wang Y., Jones P.J.H., 2004. The role of conjugated linoleic acid in human health. Dietary conjugated linoleic acid and body composition. Amer. J. Clin. Nutr. 79, 1153S-1158S