Acute cytotoxicity evoked by tetrabromobisphenol A in primary cultures of rat cerebellar granule cells outweighs the effects of polychlorinated biphenyls

• Autorzy: Zieminska E. , Stafiej A. , Toczylowska B. , Lazarewicz J. W.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to identify, among selected environmental toxins, the substance with the highest in vitro toxicity to neurons combined with the most marked induction of calcium imbalance, oxidative stress and mitochondrial dysfunction. Exposure of primary cultures of rat cerebellar granule cells for 30 min to polychlorinated biphenyls (PCBs) or brominated flame retardants (BFRs) at concentrations of 10-50 µM identified tetrabromobisphenol A as the compound with the highest toxicity. At a concentration of 25 µM, apart from the moderate activation of ⁴⁵Ca uptake, this BFR induced the most pronounced increase in intracellular Ca²⁺ concentration, depolarization of mitochondria, and activation of ROS production.

Słowa kluczowe

EN

acute cytotoxicity; tetrabromobisphenol-A; primary culture; rat; cerebellar granule cell; polychlorinated biphenyl; calcium; neurotoxicity; mitochondrial dysfunction; oxidative stress

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2012
• Tom: 21
• Numer: 4
• Opis fizyczny: p.1079-1087,fig.,ref.

Twórcy

autor

Zieminska E.

• Laboratory of Pharmaconeurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland

autor

Stafiej A.

autor

Toczylowska B.

autor

Lazarewicz J. W.

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