Calcium signaling networks in neural progenitor cells critically control cell division

• Autorzy: Rebellato P. , Malmersjo S. , Uhlen P.
• Języki publikacji: EN

Abstrakty

EN

The complex and diverse cell signaling cascades underlying neural progenitor cell division and differentiation remain poorly understood. Here we demonstrate that neural progenitor cells are forming calcium (Ca2+) networks in the embryonic brain that critically control cell division. This was observed in both BrdUpulsed animals and mouse embryonic stem (ES) cell-derived neural progenitors. The intracellular Ca2+ signal cascade is driven by electrical activity and influx of Ca2+-ions from the extracellular space. Mathematical cross-correlation analysis reveals more developed networks and stronger synchronicity of spontaneous Ca2+ activity in differentiated ES cells as compared to undifferentiated cells. The signaling mechanisms were independent of synaptic transmission and indicated that gap junctions where playing a major role in this signaling event. In summary, our results suggest a novel function for Ca2+ signaling networks in regulating cell division of neural progenitor cells.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: S
• Opis fizyczny: p.26

Twórcy

autor

Rebellato P.

• Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockolhm, Sweden

autor

Malmersjo S.

• Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockolhm, Sweden

autor

Uhlen P.

• Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockolhm, Sweden

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