Activity of natural polyether ionophores: monensin and salinomycin against clinical Staphylococcus epidermidis strains

• Autorzy: Stefanska J. , Stepien K. , Huczynski A. , Tyski S.
• Języki publikacji: EN

Abstrakty

EN

Staphylococcus epidermidis, a coagulase-negative Staphylococcus, is the most important pathogen responsible for chronic nosocomial infections. These bacteria produce extracellular slime and form biofilms on various biotic and abiotic surfaces. Bacterial biofilms are very resistant to standard antimicrobial therapy and difficult to eradicate, so it is important to search for new more effective anti-biofilm agents, for example in the group of natural substances. The aim of the study was to examine the activity of two ionophores-salinomycin and monensin against clinical S. epidermidis strains, using MIC/MBC method and biofilm formation inhibition assay. Bacterial strains were tested also for slime production using Congo Red Agar. Both tested ionophore antibiotics showed the highest activity against planktonic bacteria of clinical as well as standard S. epidermidis strains and effectively inhibited the formation of bacterial biofilm.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2015
• Tom: 64
• Numer: 3
• Opis fizyczny: p.273-278,fig.,ref.

Twórcy

autor

Stefanska J.

• Department of Pharmaceutical Microbiology, Medical University of Warsaw, Warsaw, Poland

autor

Stepien K.

• Department of Pharmaceutical Microbiology, Medical University of Warsaw, Warsaw, Poland

autor

Huczynski A.

• Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland

autor

Tyski S.

• Department of Pharmaceutical Microbiology, Medical University of Warsaw, Warsaw, Poland
• Department of Antibiotics and Microbiology, National Medicines Institute, Warsaw, Poland

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