An impact of enhanced endocannabinoid/endovanilloid neurotransmission on the behavioral effects of cocaine in rats

• Autorzy: Filip M. , Adamczyk P. , Bystrowska B. , Przegalinski E.
• Języki publikacji: EN

Abstrakty

EN

The endocannabinoid system consists of cannabinoid (CB) receptors CB1 and CB2, several endogenous ligands (e.g., anandamide and 2-arachidonoylglycerol ; 2-AG), and many membrane-bound metabolizing enzymes. Endocannabinoids and mainly CB1 receptors are important for regulation of goal-maintained behaviors as well as for different pathologies affecting these processes. CB1 receptors modulate function on dopamine transmission through indirect mechanisms involving GABA or glutamate neurons while anandamide and certain eicosanoid-derived cannabinoids may also directly activate transient receptor potential vanilloid-1 (TRPV1) channels found in some dopaminergic pathways, thus allowing a direct regulation of dopamine function. Recent, preclinical reports indicate, that drugs affected endocannabinoid/endovanilloid system may play key role in drug addiction, especially in reinstatement of cocaine seeking behavior (Filip et al. 2006). Latest results coming from our laboratories indicate a role for CB1, CB2 or TRPV1 receptors to control food self-administration but not cocaine rewarding actions. We also report inhibitory effects of CB1, CB2 or TRPV1 receptor antagonists on drug-primed cocaine-seeking behavior. Only CB1 receptor antagonism attenuated cue-induced reinstatement of cocaine seeking. Ex vivo autoradiography (CB1 receptor binding measurements) and the LC/MS system (endocannabinoid/endovanilloid levels) revealed that chronic cocaine (either active or passive administration) evokes upregulation of rat brain CB1 receptors lasting until 10 days of cocaine withdrawal while self-administered cocaine (but not given passively in a “yoked” procedure) modulates the brain levels of anandamide and 2-AG. This study was supported by the grants by the Ministry of Science and Higher Education (Poland) to P.A. and B.B., as well as by the statutory activity of the Institute of Pharmacology Polish Academy.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: S
• Opis fizyczny: p.18

Twórcy

autor

Filip M.

• Department of Pharmacology, Institute of Pharmacology PAS, Krakow, Poland
• Department of Toxicology, Faculty of Pharmacy, Jagiellonian University, Krakow, Poland

autor

Adamczyk P.

• Department of Pharmacology, Institute of Pharmacology PAS, Krakow, Poland

autor

Bystrowska B.

• Department of Toxicology, Faculty of Pharmacy, Jagiellonian University, Krakow, Poland

autor

Przegalinski E.

• Department of Pharmacology, Institute of Pharmacology PAS, Krakow, Poland

Uwagi

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