Electrophysiological diagnostics of myasthenia and myasthenic syndromes

• Autorzy: Emeryk-Szajewska B.
• Języki publikacji: EN

Abstrakty

EN

Contemporary diagnostics of neuro-muscular (n-m) transmission disorders (including myasthenia and myasthenic syndromes) comprises: (1) Pharmacological testing with edrophonium or neostigmine, (2) Immunological investigations of antibodies against AChR, MuSK and Ca channels, (3) Electrophysiological examinations: repetitive nerve stimulation (RNS) and electromyography of single muscle fibre (SFEMG) with jitter evaluation. When discussing the RNS, the physiological pathology of changes occurring during this test in the n-m junction is presented, as well as the effect of temperature on n-m transmission and the problem of n-m block selectivity. An optimal selection of muscles for such studies is proposed, taking into consideration that in n-m transmission disorders the sensitivity is higher in the proximal muscles than in the distal ones. Methods of activation of the changes looked for is discussed and an optimal investigation programme proposed. A typical myasthenic electrophysiological pattern is presented as well as that typical of Lambert-Eaton syndrome and congenital myasthenia. SFEMG method is discussed and its usefulness in diagnosing n-m transmission disturbancies. Finally, specificity and sensitivity of procedures employed in n-m transmission disturbancies is compared.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.13-14

Twórcy

autor

Emeryk-Szajewska B.

• Department of Neurology, Warsaw Medical University, Warsaw, Poland