Influence of various factors on DNA methylation in a group of elderly individuals

• Autorzy: Graban A. , Bednarska-Makaruk M. , Bochynska A. , Lojkowska W. , Mitchell M. , Ryglewicz D. , Sobczynska-Malefora A. , Wehr H.
• Języki publikacji: EN

Abstrakty

EN

In a group of 194 persons aged 54–86 years global DNA methylation was determined using Imprint DNA Quantification KitMDQ1 (Sigma-Aldrich). The association with several biochemical factors as serum glucose,serum creatinine and folic acid (determined by chemiluminescence) levels as well as with sex, age and cognitive status was estimated by multivariate stepwise regression analysis. The strongest association was stated with serum creatinine (P=0.0003), with serum folic acid (P=0.005) and with glucose (0.008) levels. The mechanisms and significance of these associations is discussed in view of human aging and age-connected diseases as atherosclerosis, diabetes and renal failure

Słowa kluczowe

EN

DNA methylation; person; biochemical factor; serum glucose level; creatinine level; folic acid level; sex; age; human aging; atherosclerosis; human disease; diabetes; renal failure

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: 1
• Opis fizyczny: p.186-187

Twórcy

autor

Graban A.

• Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Bednarska-Makaruk M.

• Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Bochynska A.

• Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Lojkowska W.

• Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Mitchell M.

• Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Ryglewicz D.

• Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Sobczynska-Malefora A.

• Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Wehr H.

• Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland