Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion

• Autorzy: Nowak I , Malinowski A , Tchorzewski H , Barcz E , Wilczynski J R , Grybos M , Kurpisz M , Luszczek W , Banasik M , Reszczynska-Slezak D , Majorczyk E , Wisniewski A , Senitzer D , Yao Sun J , Kusnierczyk P
• Języki publikacji: EN

Abstrakty

EN

Natural killer (NK) cells are the most abundant lymphocyte population in the decidua. These cells express killer immunoglobulin-like receptors (KIRs), which upon recognition of HLA class I molecules on tropho- blasts may either stimulate NK cells (activating KIRs) or inhibit them (inhibitory KIRs) to produce soluble factors necessary for the maintenance of pregnancy. KIR genes exhibit extensive haplotype polymorphism; individuals differ in both the number and kind (activating vs. inhibitory) of KIR genes. This polymorphism affects NK cell reactivity and susceptibility to diseases, including gynecological disorders. Therefore we ATR-genotyped 149 spontaneously aborting women and 117 control multiparae (at least 2 healthy-born children). Several genotypes (i.e. combinations of various KIR genes) were differently distributed among the patients and control subjects. Differences were observed in the numbers and the ratios of activating to inhibitory KIRs between patients and healthy women: (i) genotypes containing 6 activating KIR genes were less frequent and those containing 6 inhibitory KIR genes were more frequent in patients than in control subjects, and (ii) an excess of inhibitory KIRs (activating-to-inhibitory KIR gene ratios of 0.33 to 0.83) was associated with miscarriage, whereas ratios close to equilibrium (0.86-1.25) seemed to be protective. In addition, the results suggest for the first time that sporadic and recurrent spontaneous abortions as well as miscarriage in the presence or absence of autoantibodies may have different KIR genotypie backgrounds.

Słowa kluczowe

EN

killer immunoglobulin-like receptor; genotype; susceptibility; spontaneous abortion; natural killer cell

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2009
• Tom: 50
• Numer: 4
• Opis fizyczny: p.391-398,fig.,ref.

Twórcy

autor

Nowak I

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland

autor

Malinowski A

• Polish Mother's Memorial Hospital - Research Institute, Łódź, Poland

autor

Tchorzewski H

• Polish Mother's Memorial Hospital - Research Institute, Łódź, Poland

autor

Barcz E

• Medical University of Warsaw, Poland

autor

Wilczynski J R

• Polish Mother's Memorial Hospital - Research Institute, Łódź, Poland

autor

Grybos M

• Wrocław Medical University, Poland

autor

Kurpisz M

• Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland

autor

Luszczek W

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland

autor

Banasik M

• Polish Mother's Memorial Hospital - Research Institute, Łódź, Poland

autor

Reszczynska-Slezak D

• Wrocław Medical University, Poland

autor

Majorczyk E

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland

autor

Wisniewski A

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland

autor

Senitzer D

• City of Hope National Medical Center, Duarte, CA, USA

autor

Yao Sun J

• City of Hope National Medical Center, Duarte, CA, USA

autor

Kusnierczyk P

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland
• Jan Długosz Pedagogical University, Częstochowa, Poland

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