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1997 | 44 | 1 |

Tytuł artykułu

Activity of cancer procoagulant [CP] in serum of patients with cancer of lung, breast, oesophagus and colorectum

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Activity of cancer procoagulant (CP) was studied in blood serum of 90 patients with cancer of lung, breast, oesophagus and colorectum, and of 15 healthy people. The activity of CP was determined by the coagulation method. Sera of patients with cancer showed higher mean activity of CP than sera of healthy control. Of the 90 cancer patients 78 were identified correctly by this test as having cancer (sensitivity 85%). In the case of lung and colorectal cancers the higher CP activity was observed the more advanced was the clinical stage of cancer, and the test was positive in 100%. After radical removal of malignant tumor of lung, decreased CP activity was found.

Wydawca

-

Rocznik

Tom

44

Numer

1

Opis fizyczny

p.109-112

Twórcy

autor
  • Medical Academy in Bialystok, Ogrodowa 12, 15-027 Bialystok, Poland
autor
autor

Bibliografia

  • 1. Gordon, S.G., Franks, J.J. & Lewis, B. (1975) Cancer procoagulant A: A factor X activating procoagulant from malignant tissue. Throm­bos. Res. 6, 127-137.
  • 2. Gordon, S.G. (1994) Cancer procoagulant. Methods Enzymol. 244, 568-583.
  • 3. Gordon, S.G. & Chelladurai, M. (1992) Non- tissue factor procoagulants in cancer cells. Cancer Methastas. Rev. 11, 267-282.
  • 4. Gordon, S.G. & Benson, B. (1989) Analysis of serum cancer procoagulant activity and its possible use as a tumor marker. Thrombos. Res. 56, 431-440.
  • 5. Kozwich, D.L., Kramer, L.C., Mielicki, W.P., Fotopoulos, S.S. & Gordon, S.G. (1994) Appli­cation of cancer procoagulant as an early de­tection tumor marker. Cancer 74, 1367-1376.
  • 6. Falanga, A. & Gordon, S.G. (1985) Compari­son of properties of cancer procoagulant and human amnion-chorion procoagulant. Bio- chim. Biophys. Acta 831, 161-165.
  • 7. Gordon, S.G. & Cross, B.A. (1990) An enzyme- linked immunosorbent assay for cancer pro­coagulant and its potential as a new tumor marker. Cancer Res. 50, 6229-6234.
  • 8. Mielicki, W. & Wierzbicki, R. (1990) Cancer procoagulant in serum of rats during develop­ment of experimental epithelioma. Int. J. Cancer 45, 125-126.
  • 9. Donati, M.B., Falanga, A., Consonni, R., Ale- sio, M.G., Bassan, R., Buelli, M., Borin, L., Catani, L., Pogliani, E. & Gugliotta, L. (1990) Cancer procoagulant in acute non lymphoid leukemia: Relationship of enzyme detection to disease activity. Thrombos. Haemostas. 64, 11-16.

Typ dokumentu

Bibliografia

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Identyfikator YADDA

bwmeta1.element.agro-article-fe7fe4c8-7f08-455b-b36a-dee62e235e9b
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