EN
The aim of the study was to test safety, immunogenicity and protective values of an experimental vaccine against rotaviral diarrhoeas in piglets. Laboratory experiments were carried out on 14 pregnant multiparous sows and 212 conventional piglets aged from 1 day to 5 weeks. Field observations were performed on 262 sows and their offspring. In the studies regarding immunogenic properties of the prepared vaccine, the Ambico biopreparation (Dallas Center, USA) was also used as a positive control. In order to assess immunogenic properties of the prepared vaccine two E. coli vaccines i.e. Colivac S-2 and Nobi-Vac Porcoli were included in the field experiments. Laboratory and field safety tests showed that the vaccination of piglets does not cause any disorders in the general health and no local side-reactions were observed in the piglets. Serological examinations revealed high immunogenic properties of the antigen chosen for the vaccine production. Field experiments demonstrated that the administration of the vaccine for prophylaxis of rotaviral porcine diarrhoeas in suckling piglets was very useful.