dUTP pyrophosphatase as a potential target for chemotherapeutic drug development

• Autorzy: McIntosh E. M. , Haynes R.H.
• Języki publikacji: EN

Abstrakty

EN

Aberrant dUTP metabolism plays a critical role in the molecular mechanism of cell killing induced by inhibitors of dihydrofolate reductase and thymidylate synthase. While considerable effort has been directed towards discovering new, more potent inhibitors of these two enzymes, little attention has been given dUTP pyrophosphatase (dUTPase)--the key modulator of cellular dUTP levels--as a potential target for chemotherapeutic drug development. Recent studies have provided evidence that dUTPase is vital for cellular and, in some cases, viral DNA replication. Furthermore, some retroviruses encode dUTPases--a fact which suggests that cellular dUTP metabolism may be more important than previously realized. Here, we briefly review current knowledge of cellular and viral dUTPases and discuss the potential of these enzymes as targets for cancer chemotherapeutic and anti-viral drug development.

Słowa kluczowe

EN

retrovirus; thymineless death; chemotherapy; enzyme level; dUTPase; chemotherapeutic target; chemotherapeutic drug; DNA; inhibitor; cancer; pyrophosphatase; cellular system

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1997
• Tom: 44
• Numer: 2
• Opis fizyczny: p.159-171,fig.

Twórcy

autor

McIntosh E. M.

• York University, 4700 Keele Street, Toronto, Canada M3J 1P3

autor

Haynes R.H.

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