Heterologous expression of genes in filamentous fungi

• Autorzy: Kruszewska J. S.
• Języki publikacji: EN

Abstrakty

EN

Isolation of some biologically important proteins from natural sources was found to be too expensive or scarcely possible (human proteins). The problem could be solved by expression of heterologous genes. Many biologically active proteins have been successfully expressed in filamentous fungi, some of them, however, at a low level. Thus, improvement of this technique appears to be a very important task. The process comprises several steps. Some of them, such as efficient transformation, vector construction, processing of signal sequences, post-translational modifications and secretion of the expressed proteins, have been intensively investigated. This review presents obstacles and problems encountered in expression of heterologous genes and discusses strategies of development in this area.

Słowa kluczowe

EN

gene expression; human protein; filamentous fungi; fungi

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 1
• Opis fizyczny: p.181-195

Twórcy

autor

Kruszewska J. S.

• Polish Academy of Sciences, A.Pawinskiego 5a, 02-106 Warsaw, Poland

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