Novel nociceptin analogues

• Autorzy: Bartosz-Bechowski H. , Miedzybrodzki R. , Szymaniec S.
• Języki publikacji: EN

Abstrakty

EN

A series of new nociceptin analogues containing cysteine was tested for their noci­ceptive effects in tail-flick test on mice after icv injection. The cysteines were intro­duced in order to get irreversibly binding analogues based on the assumption that the cysteines in the ligand can interact with the cysteines from the receptor to form an S-S bridge. In vivo tests revealed that CysX-nociceptin (1-13)-NH2 (Cys1-NC) is an antagonist, whereas Cys7-NC is an agonist. Gly1 ,[Phe(p-NO2)]4 -NC was less active indi­cating that the antagonist properties of Cys1-NC are associated with the presence of the sulfhydryl group of cysteine. The analogues D-Cys2 and Cys3 were also almost in­active.

Słowa kluczowe

EN

cysteine; neuropeptide; nociceptin; antagonist; cloning; orphanin; opioid receptor; injection; antiopioid

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1155-1158,fig.

Twórcy

autor

Bartosz-Bechowski H.

• University of Wroclaw, F.Joliot-Curie 14, 50-383 Wroclaw, Poland

autor

Miedzybrodzki R.

autor

Szymaniec S.

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