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Czasopismo

2004 | 63 | 2 |

Tytuł artykułu

Effect of acute exposure to cadmium on the expression of calcitonin gene-related peptide [CGRP], calcitonin [CT], somatostatin [SST] and synaptophysin [SYN] in the C cells of the rat thyroid - a preliminary study

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the present study was to determine to what degree acute exposure to cadmium affects the expression of CGRP, CT, SST and SYN in the C cells of the rat thyroid. Animals from 7 experimental groups received CdCl₂ iv. in doses of 3.5, 3, 2.5, 2, 1.5, 1 and 0.5 mg/kg b.w. respectively, while the control animals were given 0.9% NaCl iv. 24 hours after the iv. administration of CdCl₂, a correlation was found between a single dose of cadmium and the intensity of the immunocytochemical reactions for CGRP, CT, SST and SYN in C cells of the rat thyroid when compared to the control. The weakest immunocytochemical reactions were noted in C cells of the thyroid of rats from Groups I and II, their intensity gradually increasing in Groups III, IV and V in comparison to the control. The reaction intensity in animals of Groups VI and VII resembled those of the control.

Wydawca

-

Czasopismo

Rocznik

Tom

63

Numer

2

Opis fizyczny

p.217-219,fig.,ref.

Twórcy

autor
  • Medical University, Kilinskiego 1, 15-089 Bialystok, Poland
autor

Bibliografia

  • 1. Osius N, Karmaus W, Kruse H, Witten J (1999) Exposure to polychlorinated biphenyls and levels of thyroid hormones in children. Environ Health Perspect, 107: 843–849.
  • 2. Gupta P, Kar A (1998) Role of ascorbic acid in cadmium-induced thyroid dysfunction and lipid peroxidation. J Appl Toxicol, 18: 317–320.
  • 3. Pavia Jr MA, Noli MI, Hagmuuller K, Zaninovich AA (1997) Evidence suggesting that cadmium induces a non-thyroid illness syndrome in the rat. J Endocrinol, 154: 113–117.
  • 4. Piłat-Marcinkiewicz B, Sawicki B, Brzóska M, Zabel M (2001) Preliminary immunohistochemical study of C cells of the thyroid and endocrine cells of the parathyroid glands in rats after prolonged exposure to cadmium. Folia Histochem Cytobiol, 39: 191–192.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-da3a85f5-dabd-422b-94a7-3e202bdf3af2
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