Chirurgiczne aspekty pobierania nerek u swin dla celow ksenotransplantacji

• Autorzy: Skucinski J , Nowak W. , Wieczorek J. , Solecki R.

Warianty tytułu

EN

Surgical aspects of pig kidneys collection for xenotransplantation

• Języki publikacji: PL

Abstrakty

EN

The number of patients waiting for transplants has increased despite the constant growth of the number of transplants performed. This is the reason why the possibility of using animal organ donors is taken into consideration. Since 2002, the problems concerning xenotrasplantation have been investigated in Poland in the frame of the project: Application of trangenesis in genetic modification of pigs in order to gain organs for transplantation in humans. In the presented paper the possibility of use of transgenic pig kidneys for allogenic and heterogenic transplantation in clinical aspect was evaluated, with the special compliance of surgical methods. The proposed surgical technique of kidney transplantation in pigs derived from the methods used in human medicine and consisted of three stages: the operation of collecting the kidneys en-block, preservation of collected organs and their transplantation. The aim of the first stage was the isolation of the both donor kidneys as fast as possible in a manner not causing the injury of kidney parenchyma, with the maintenance of all anatomical and functional structures and blood vessels. In the study, 3 non-transgenic and 6 transgenic sows with the block of the gene á1,3GT were evaluated. In the presented studies the modification of the routine technique of kidney collection used in human transplantology was performed with the possibility of application of the method for allo- and xenotranplantation in pigs. The maintenance of the defined conditions of perfusion and storage of the collected organs is the requirement of the preservation of viability of the transplant for the time necessary for preparing the organ and the recipient for the transplantation.

Słowa kluczowe

PL

trzoda chlewna; nerki; chirurgia weterynaryjna; ksenotransplantacje; transplantologia; pobieranie narzadow

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 07
• Opis fizyczny: s.815-818,rys.,bibliogr.

Twórcy

autor

Skucinski J

• Uniwersytet Jagiellonski, ul.Kopernika 40, 31-501 Krakow

autor

Nowak W.

autor

Wieczorek J.

autor

Solecki R.

Bibliografia

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