Formation of lipid droplets induced by 2,3-dihydrogeranylgeranoic acid distinct from geranylgeranoic acid

• Autorzy: Kodaira Y. , Kusumoto T. , Takahashi T. , Matsumura Y. , Miyagi Y. , Okamoto K. , Shidoji Y. , Sagami H.
• Języki publikacji: EN

Abstrakty

EN

Geranylgeranoic acid (GGA) and 2,3-dihydrogeranylgeranoic acid (2,3-diGGA) are geranylgerani-ol-derived metabolites (Kodaira et al.(2002) J Biochem132:327–334). In the present study, we examined the effects of these acids on HL-60 cells. The cells were differentiated into neutrophils by GGA stimulation like retinoic acid stimulation. In the case of cells stimulated with 2,3-diGGA, neutrophils were not detected, but the formation of lipid droplets was induced. On the other hand, when the cells were cultured in the presence of 0.1% FBS instead of 10% FBS, apoptotic cells were induced not only by GGA stimulation but also with 2,3-diGGA. In the latter case, when the cells were cultured in the co-presence of a caspase-3 inhibitor (Ac-DMQD-CHO), the lipid droplets formation was observed in the cells. These results suggest that GGA and 2,3-diGGA are extremely different from each other with respect to their effects on HL-60 cells.

Słowa kluczowe

PL

HL-60 cell; neutrophil; lipid droplet; 2,3-dihydrogeranylgeranoic acid; geranylgeranoic acid; metabolite; formation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2007
• Tom: 54
• Numer: 4
• Opis fizyczny: p.777-782,fig.,ref.

Twórcy

autor

Kodaira Y.

• Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, 980-8577, Japan

autor

Kusumoto T.

autor

Takahashi T.

autor

Matsumura Y.

autor

Miyagi Y.

autor

Okamoto K.

autor

Shidoji Y.

autor

Sagami H.

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