Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell

• Autorzy: Ochocka A. M. , Pawelczyk T.
• Języki publikacji: EN

Abstrakty

EN

Phospholipase C (PLC, EC 3.1.4.11) is an enzyme crucial for the phosphoinositol pathway and whose activity is involved in eukaryotic signal transduction as it gener­ates two second messengers: diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). There are four major types of phospholipase C named: β,γ,δ and the recently discovered ε, but this review will focus only on the recent advances for the ó isozymes of PLC. So far, four δ isozymes (named (δ1-4) have been discovered and ex­amined. They differ with regard to cellular distribution, activities, biochemical fea­tures and involvement in human ailments.

Słowa kluczowe

EN

phosphoinositol; structure; eukaryotic cell; cell; inositol 1,4,5-triphosphate; regulation; enzyme; isoenzyme; signal transduction; phospholipase

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2003
• Tom: 50
• Numer: 4
• Opis fizyczny: p.1097-1110,fig.,ref.

Twórcy

autor

Ochocka A. M.

• Medical University of Gdansk, Debinki 7, paw.29, 80-211 Gdansk, Poland

autor

Pawelczyk T.

Bibliografia

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