Capsaicin induced deafferentiation enhances the effect of electrical vagal nerve stimulation on food intake and body mass

• Autorzy: Laskiewicz J. , Krolczyk G. , Zurowski D. , Enck P. , Thor P.J.
• Języki publikacji: EN

Abstrakty

EN

Study was based on hypothesis that electrical stimulation (ES) with parameters obtained from analysis of vagal afferent discharge fed state may fake brain with satiety state. We evaluated effect of denervation of vagal capsaicin-sensitive afferents on food intake and body weight in rats with ES of vagal nerves using microchip (MC). Group A was scheduled to MC implantation, B to sham operation only, C to MC implantation and capsaicin vagal deafferentation, and D to capsaicin denervation only. ES lasted 24 days. MC parameters were 0.05Hz, 0.1s, 0.55V. ES of left vagus significantly reduced total food intake as well as the mean daily intake in groups A and C in comparison to control and D group (ANOVA, F=18.55, p=0.0038). Body weight was lower in group A (346,2 g) and C (272,7 g) then in control (381,4 g) and D (356,8 g) (F=25.68, p=0.00068). Leptin decreased in C (165 pg/mL) in comparison to A (625 pg/mL), B (677 pg/mL), and D (612 pg/mL) (p<0,05), mainly due to ES (F=7.27, p=0.019). Glucose was decreased in A (F=5.55, p=0.036) - by 11 % and by 16% in C group. Proper vagal neuromodulation results in central and peripheral effects causing food intake and body weight downregulation.

Słowa kluczowe

EN

vagus nerve; capsaicin; food intake; body weight; body mass; vagus stimulation; electrical stimulation

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2004
• Tom: 55
• Numer: 1,2
• Opis fizyczny: p.155-163,fig.,ref.

Twórcy

autor

Laskiewicz J.

• Jagiellonian University Medical College, Czysta 18, 31-121 Krakow, Poland

autor

Krolczyk G.

autor

Zurowski D.

autor

Enck P.

autor

Thor P.J.