The effect of nebivolol on atherogenesis in apoE - knockout mice

• Autorzy: Kus K. , Gajda M. , Pyka-Fosciak G. , Toton-Zuranska J. , Pawlowska M. , Suski M. , Niepsuj A. , Nowak B. , Wolkow P. , Olszanecki R. , Jawien J. , Korbut R.
• Języki publikacji: EN

Abstrakty

EN

Nebivolol is a novel beta1-blocker with a nitric oxide (NO) - potentiating, vasodilatory effect that is unique among beta-blockers. It was already shown that nebivolol ameliorates atherosclerosis in cholesterol-fed rabbits. We, therefore, wanted to investigate whether this is the case in the fine experimental model of atherosclerosis: apolipoprotein E (apoE)- knockout mice. Nebivolol attenuated atherogenesis, measured both by "en face" method (9.23±1.8% vs. 14.6±2.1%) and "cross-section" method (63125±8455 µm2 vs. 91416±8357 m2). This is the first report showing the effect of nebivolol on atherogenesis in gene-targeted mice.

Słowa kluczowe

EN

nebivolol; atherogenesis; apolipoprotein E; knockout mice; knockout mouse; beta1-blocker; nitric oxide; atherosclerosis

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2009
• Tom: 60
• Numer: 4
• Opis fizyczny: p.163-165,fig.,ref.

Twórcy

autor

Kus K.

• Jagiellonian University Medical College, Grzegorzecka Str. 16, 31-531 Krakow, Poland

autor

Gajda M.

autor

Pyka-Fosciak G.

autor

Toton-Zuranska J.

autor

Pawlowska M.

autor

Suski M.

autor

Niepsuj A.

autor

Nowak B.

autor

Wolkow P.

autor

Olszanecki R.

autor

Jawien J.

autor

Korbut R.