The interaction of daunorubicin and mitoxantrone with the red blood cells of acute myeloid leukemia patients

• Autorzy: Marczak A , Wrzesien-Kus A. , Krykowski E. , Robak T. , Jozwiak Z.
• Języki publikacji: EN

Abstrakty

EN

The effect of DNR and MIT on erythrocyte membrane structure was examined using Electron Spin Resonance spectroscopy and the fluorimetric technique. The results suggest that the in vivo interaction of the drugs with the RBCs of AML patients led to a perturbation in the structure of plasma membrane components. Differences between DNR and MIT were only noted in the interaction of the drugs with deeper regions of the lipid bilayer.

Słowa kluczowe

EN

interaction; daunorubicin; leukemia; drug; anthracycline daunorubicin; mitoxantrone; plasma membrane; patient; lipid bilayer; treatment; erythrocyte; therapy; acute myeloid leukemia

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 4
• Opis fizyczny: p.885-890,fig.

Twórcy

autor

Marczak A

• University of Lodz, Banacha 12-16, 90-237 Lodz, Poland

autor

Wrzesien-Kus A.

autor

Krykowski E.

autor

Robak T.

autor

Jozwiak Z.

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