Effects of two types of restraint stress on spontaneous behavior of Sprague-Dawley and Lewis rats

• Autorzy: Klenerova V. , Sida P. , Krejci I. , Hlinak Z. , Hynie S.
• Języki publikacji: EN

Abstrakty

EN

The purpose of this study was to evaluate the action of two types of stressors in Sprague-Dawley (S-D) and Lewis (LEW) rats differing in their hypothalamic-pituitary-adrenal axis activity on locomotion and rearing in an open space. Exposure to restraint immobilization alone (IMO) or this immobilization combined with cold water (22 °C) immersion (IMO+C) lasted for 1 h and started 2 or 5 h before the test. To evaluate the acute and persisting effects of both stressors, four trials were performed in one-week intervals; rats were exposed to the stressors in trial 1 and 3. While in LEW rats both acute stressors produced reduction of locomotion and rearing in all stressed groups, S-D rats responded with a decrease of both parameters only after IMO+C presented 2 h before testing. Neither strain displayed a changed performance one week after the first stress exposure. One week after the second stress exposure rats of both strains exhibited a tendency to an increase of both parameters reaching the significance in several experimental groups. The findings indicate: a) the IMO+C produced stronger behavioral alteration than IMO alone; b) the behavioral responses to stressors were more pronounced in LEW compared to S-D strain; c) change from the reduction of activity to its increase may be interpreted as bi-directional manifestation of long-term effects of immobilization stress.

Słowa kluczowe

EN

Lewis rat; exploratory activity; immobilization; stressor; Sprague-Dawley rat; rat; cold stress; hypothalamic-pituitary-adrenal axis

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2007
• Tom: 58
• Numer: 1
• Opis fizyczny: p.83-94,fig.,ref.

Twórcy

autor

Klenerova V.

• Charles University in Prague, Albertov 4, 128 00 Prague 2, Czech Republic

autor

Sida P.

autor

Krejci I.

autor

Hlinak Z.

autor

Hynie S.