The effect of undecanones and their derivatives on tumor angiogenesis and VEGF content

• Autorzy: Gibka J. , Wasiutynski A. , Skopinska-Rozewska E. , Siwicki A.K. , Chorostowska-Wynimko J. , Sommer E. , Mazurkiewicz M. , Glinski M. , Skurzak H. , Wojcik R. , Jung L.
• Języki publikacji: EN

Abstrakty

EN

The in vivo effects of some derivatives of aliphatic ketones (2-undecanone, 3-undecanone, 4-undecanone and their derivatives) on L-l sarcoma tumor angiogenesis and VEGF content were studied in Balb/c mice. Mice that inhaled 10% solution of 3-undecanone(3-on) or 1% solution of 2-undecanone propylene acetal (Acpr2) for 3 days after tumor cells implantation, presented lower neovascular response measured by tumor-induced cutaneous angiogenesis test (TIA) and lower tumor VEGF content in 5-days tumors, than non-inhaled controls. Other substances presented various effects on tumor VEGF concentration and angiogenesis. Histological examination of lesions collected from mice inhaled Acpr2, or non-inhaled controls, revealed small diffused areas of necrosis in the former group. In both groups, slight to moderate inflammatory infiltrations were seen at the tumor's margin. In Acpr2 group, there were less small blood vessels at tumor's margin than in the control group.

Słowa kluczowe

EN

mice; mouse; undecan-x-one; derivative; angiogenesis; tumour; VEGF zob.vascular endothelial growth factor; enantiomer; histological examination; vascular endothelial growth factor; sarcoma cell

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2010
• Tom: 13
• Numer: 1
• Opis fizyczny: p.105-115,fig.,ref.

Twórcy

autor

Gibka J.

• Technical University of Lodz, Stefanowskiego 4/10, 90-924 Lodz, Poland

autor

Wasiutynski A.

autor

Skopinska-Rozewska E.

autor

Siwicki A.K.

autor

Chorostowska-Wynimko J.

autor

Sommer E.

autor

Mazurkiewicz M.

autor

Glinski M.

autor

Skurzak H.

autor

Wojcik R.

autor

Jung L.