A study of the genotoxic potential of flavonoids using short-term bacterial assays

• Autorzy: Czeczot H. , Kusztelak J.
• Języki publikacji: EN

Abstrakty

EN

Genotoxic activities of flavonoids (quercetin, rhamnetin, isorhamnetin, apigenin, Iuteolin) were investigated using two short-term bacterial assays. In the "repair test" in Salmonella typhimurium (strains TA1538 uvrB' and TA1978 uvrB+) the flavonoids studied did not introduce any damage into the DNA recognized by UvrABC nuclease (correndonuclease II). The results of the SOS-Chromotest in Escherichia coli K-12 strains PQ37 (tag*, alk+) and PQ243 (tagA, alkA) indicated that flavonoids only weakly induced the SOS system. The addition of a liver activation system (S9 mix) did not increase the mutagenic effect of the flavonoids tested. Two compounds: rhamnetin, isorhamnetin and their putative metabolites formed in the presence of the S9 mix did not alkylate DNA at N-3 of adenine.

Słowa kluczowe

EN

diet; flavonoids; genotoxic potential; rhamnetin; man; Salmonella typhimurium; chemical structure; bacteria; Escherichia coli; isorhamnetin; vegetable; fruit

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1993
• Tom: 40
• Numer: 4
• Opis fizyczny: p.549-554,fig.

Twórcy

autor

Czeczot H.

• Warsaw Medical School, S.Banacha 1, 02-097 Warsaw, Poland

autor

Kusztelak J.

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