The role of labile iron pool in cardiovascular diseases

• Autorzy: Kruszewski M.
• Języki publikacji: EN

Abstrakty

EN

Although multiple factors are associated with cardiovascular pathology, there is now an impressive body of evidence that free radicals and nonradical oxidants might cause a number of cardiovascular dysfunctions. Both direct damage to cellular com­ponents and/or oxidation of extracellular biomolecules, e.g. LDL, might be involved in the aetiology of cardiovascular diseases. The key molecules in this process seem to be iron and copper ions that catalyse formation of the highly reactive hydroxyl radi­cal. Chelation of iron ions has a beneficial effect on the processes associated with the development of atherosclerosis and formation of post-ischemic lesions. These find­ings are indirectly supported by the increasing body of evidence that stored body iron plays a crucial role in pathogenesis of atherosclerosis and ischemia/reperfusion injury.

Słowa kluczowe

EN

iron ion; aetiology; copper ion; reactive nitrogen species; reactive oxygen species; oxidative stress; ischaemia; cardiovascular disease; free radical; reperfusion; atherosclerosis; nonradical oxidant

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 2
• Opis fizyczny: p.471-480,fig.,ref.

Twórcy

autor

Kruszewski M.

• Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland

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