Zmiana odpowiedzi immunologicznej u myszy BALB/c w koinwazji Heligmosomoides polygyrus i Trichinella spiralis

• Autorzy: Doligalska M , Rzepecka J. , Moskwa B. , Laskowska M.
• Języki publikacji: PL

Abstrakty

EN

The influence of Heligmosomoides polygyrus on infection with Trichinella spiralis was studied in BALB/c mice. Mice coinfected with T. spiralis and previously given H. Polygyrus harboured both nematode species till day 34. The number of T. spiralis muscle larvae was greater in mice coinfected with H. polygyrus/T. spiralis or T. spiralis/H. polygyrus than after infection with T. spiralis alone. Infection with H. polygyrus did not enhance eosinophil and IL-5 levels induced by T. spiralis. Additionally, the production of IgG1 specific to LI T. spiralis was inhibited by co-infection. Changes in the levels of IFN-y and IgG2a implicated a disturbance in Th2 cell activation during protective response and resulted in the greater number of T. spiralis muscle larvae in coinfected mice.

Słowa kluczowe

PL

odpowiedz immunologiczna; koinwazja; zwierzeta doswiadczalne; Trichinella spiralis; parazytologia; myszy; Heligmosomoides polygyrus; nicienie; pasozyty; inwazja pasozytnicza

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 2001
• Tom: 47
• Numer: 4
• Opis fizyczny: s.735-739,tab.,bibliogr.

Twórcy

autor

Doligalska M

• Uniwersytet Warszawski, ul.Miecznikowa 1, 02-096 Warszawa

autor

Rzepecka J.

autor

Moskwa B.

autor

Laskowska M.

Bibliografia

• BEHNKE J. M., CABAJ W., WAKELIN D. 1992. Susceptibility of adult Heligmosomoides polygyrus to intestinal intlammatory responses induced by heterologous infection. Int. J. Parasitol. 22: 75-86.
• DOLIGALSKA M., MIJAL J. 2000. IgG1 and IgG2a response specific to Trichinella spiralis during subsequent infection with Heligmosomoides polygyrus in BALB/c mice. Acta Parasit. 45: 115-120.
• DOLIGALSKA M., LASKOWSKA M. 2000. Inhibition of the protective IgA response by ketotifen is related to the inflammatory reaction in the peritoneal cavity and intestinal mucosa of BALB/c mice infected with Trichinella spiralis. Acta Parasit. 45: 115-120.
• GRENCIS R. K. 1997. Th2-mediated host protective immunity to intestinal nematode infections. Philos. Trans. R. Soc. Land. Biol. Sci. 352: 1377-1384.
• KAZURA J. W., GROVE D. I. 1978. Stage-specific antibody-dependent eosinophil-mediated destruction of Trichinella spiralis. Nature 274: 588.
• SHI H. N., KOSKI K. G., STEVENSON M. M., SCOTT M. E. 1997. Zinc deficiency and energy restriction modify immune responses in mice during both primary and challenge infection with Heligmosomoides polygyrus (Nematoda). Parasite Immunol. 19: 363-373.
• TELFORD G., WHEELER D. J., APPLEBY P., BOWEN J. G., PRITCHARD D. I. 1998. Heligmosomoides polygyrus immunomodulatory factor (IMF), targets T-lymphocytes. Parasite Immunol. 20: 601-611.
• YAMAGUCHI Y., SUDA T., SUDA J.. EGUCHI M., MIURA Y., HARADA N., TOMINAGA A., TAKATSU K. 1988. Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J. Exp. Med. 167: 43-56.