Actin in human colon adenocarcinoma cells with different metastatic potential

• Autorzy: Nowak D. , Krawczenko A. , Dus D. , Malicka-Blaszkiewicz M.
• Języki publikacji: EN

Abstrakty

EN

Four human colon adenocarcinoma cell line variants with different metastatic po­tential were used to examine whether a correlation exists between actin level, state of actin polymerization and invasiveness of tumour cells. Monomeric (G), total (T) and filamentous (F) actin were determined in the cytosolic fraction of these cells. A statistically significant decrease in G actin level and increase in the state of actin polymerization (measured by F:G actin ratio) were found in the cytosol of three cell variants with higher metastatic potential and invasiveness (EB3, 3LNLN, 5W) compared with the parental cell line (LS180). Our experimental data lead to the conclusion that there is a correlation between the metastatic capacity of human colon adenocarcinoma cells and the state of actin poly­merization.

Słowa kluczowe

EN

cell line; eukaryotic cell; tumour cell; cell; man; structural function; signal transduction; actin; adenocarcinoma; motile function; cytokinesis; colon

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 4
• Opis fizyczny: p.823-828,fig.

Twórcy

autor

Nowak D.

• University of Wroclaw, S.Przybyszewskiego 63, 51-148 Wroclaw, Poland

autor

Krawczenko A.

autor

Dus D.

autor

Malicka-Blaszkiewicz M.

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