Zmiany morfologiczne jajnika i macicy po antykoncepcji estrogenowej u suk

• Autorzy: Jurka P , Snochowski M. , Boryczko Z.

Warianty tytułu

EN

Estrogen contraception in bitches - the effect of dose on morphological changes in ovary and uterus

• Języki publikacji: PL

Abstrakty

EN

In the present study we have evaluated the effect of estrogen contraception on ovarian and uterine morphology in healthy bitches. 30 crossbreed bitches with physiological estrous cycle (1-3 y; 10-14 kg) were divided into control (n = 6) and two experimental groups of 12 bitches treated twice with different doses of estradiol benzoate (EB). The first group received 10 µg EB/kg BW (Mesalin, Intervet), and the second 100 µg EB/kg BW (Oestradiolum benzoicum, Polfa), given i.m. on day 3 and 5 after the first acceptance of a male. The ovaries and uteri were collected 14 or 28 days from the first EB injection. The histopathological evaluation and histomorphometric measurements were performed using computer assisted analysis. There was no significant effect of estrogen treatment on ovarian activities at either dose. The uteri of bitches from the control group have shown progressive regression of all endometrial elements typical for the middle part of the luteal phase of the estrous cycle. The low dose EB treatment caused glandular hyperplasia characteristic for early stages of cystic formation. The higher dose resulted in total inhibition of cell proliferation, stimulation of glandular hyperplastic (complex) changes and increased thickness of the uterine wall. At the latter time the cystic changes within the glandular part may cause endometritis or even pyometra. The results obtained indicate the need for clinical follow up of bitches treated with estrogens.

Słowa kluczowe

PL

psy; zmiany morfologiczne; estrogeny; macica; suki; zmiany histopatologiczne; jajniki; antykoncepcja hormonalna

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 08
• Opis fizyczny: s.985-989,fot.,tab.,bibliogr.

Twórcy

autor

Jurka P

• Szkola Glowna Gospodarstwa Wiejskiego, ul.Nowoursynowska 159 C, 02-766 Warszawa

autor

Snochowski M.

autor

Boryczko Z.

Bibliografia

• 1.Barrau D. M., Abel J. H., Verhage H. G., Tietz W. J.: Development of the endometrium during the estrus cycle in the bitch. Am. J. Anat. 1976, 142, 47-66.
• 2.Boryczko Z., Katkiewicz M., Bostedt H., Gajewski Z.: Ropomacicze u suk - etiopatogeneza, objawy, rozpoznawanie i leczenie. Medycyna Wet. 2001, 57, 246-250.
• 3.Bowen R. A., Olson P. N., Behrendt M. D., Wheeler S. L., Husted W., Nett T. M.: Efficacy and toxicity of estrogens commonly used to terminate canine pregnancy. J. Am. Vet. Med. Assoc. 1985, 186, 783-788.
• 4.Concannon P.: Reproductive endocrinology, contraception and pregnancy termination in dogs, [w:] Ettinger S., Feldman E.: Textbook of Veterinary Internal Medicine. Saunders W. B., Philadelphia 1995, 1625-1636.
• 5.Concannon P. W., Meyers-Wallen V. N.: Current and proposed methods for contraception and termination of pregnancy in dogs and cats. J. Am. Vet. Med. Assoc. 1991, 198, 1214-1225.
• 6.De Bosschere H., Ducatelle R., Tshamala M.: Uterine oestrogen and progesterone receptor expression in experimental pyometra in the bitch. J. Comp. Pathol. 2003, 128, 99-106.
• 7.Dhaliwal G. K., England G. C., Noakes D. E.: The effects of endometrial scarification on uterine steroid receptors, bacterial flora and histological structure in the bitch. Anim. Reprod. Sci. 2002, 69, 239-249.
• 8.Dhaliwal G. K., England G. C., Noakes D. E.: The influence of exogenous steroid hormones on steroid receptors, uterine histological structure and the bacterial flora of the normal bitch. Anim. Reprod. Sci. 1999, 56, 259-277.
• 9.Fong K., Causer O., Atri M., Lytwyn A., Kung R.: Transvaginal US and hysterosonography in postmenopausal women with breast cancer receiving tamoxifen: correlation with hysteroscopy and pathologic study. Radiographics 2003, 23, 137-150.
• 10.Hoffmann B., Riesenbeck A., Schams D., Steinetz B. G.: Aspects on hormonal control of normal and induced parturition in the dog. Reprod. Dom. Anim. 1999, 34, 219-226.
• 11.Jeffcoate I. A.: Endocrinology of anoestrous bitches. J. Reprod. Fertil. Suppl. 1993, 47, 69-76.
• 12.Jurka P.: Ocena zmian zachodzących w macicy i jajnikach po stosowaniu steroidowych preparatów antykoncepcyjnych u suk. Praca dokt., SGGW, Warszawa 1999.
• 13.Kim K. S., Kim O.: Cystic endometrial hyperplasia and endometritis in a dog following prolonged treatment of medroxyprogesterone acetate. J. Vet. Sci. 2005, 6, 81-82.
• 14.Krzyżanowski J.: Ropomacicze u suk. Medycyna Wet. 1994, 50, 436-438.
• 15.Kurman R. J., Norris H. J.: Endometrial hyperplasia and related cellular changes, [w:] Kurman R. J.: Blaustein's pathology of the female genital tract. Springer-Verlag, New York 1994, 411-437.
• 16.Moczko J. A., Brębowicz H. G., Tadeusiewicz R.: Statystyka w badaniach medycznych. PWN, Warszawa 1998.
• 17.Noakes D. E., Dhaliwal G. K., England G. C.: Cystic endometrial hyperplasia/pyometra in dogs: a review of the causes and pathogenesis. J. Reprod. Fertil. Suppl. 2001, 57, 395-406.
• 18.Ronnett B. M., Kurman R. J.: Precursor lesions of endometrial carcinoma, [w:] Kurman R.: Blaustein's Pathology of the Female Genital Tract. Springer-Verlag, New York 2002, 467-500.
• 19.Schoon H. A., Schoon D., Nolte I.: Investigations on the pathogenesis of the endometritis-pyometra-complex in the bitch. J. Vet. Med. A. 1992, 39, 43-56.
• 20.Scully R. E., Bonfiglio T. A., Kurman R. J., Silverberg S. G., Wilkinson E. J.: Histological Typing of Female Genital Tract Tumours (International Histological Classification of Tumours), WHO, Geneva 1994, 13-18.
• 21.Sutton D. J., Geary M. R., Bergman J. G.: Prevention of pregnancy in bitches following unwanted mating: a clinical trial using low dose oestradiol benzoate. J. Reprod. Fertil. Suppl. 1997, 51, 239-243.
• 22.Tsutsui T., Mizutani W., Hori T., Oishi K., Sugi Y., Kawakami E.: Estradiol benzoate for preventing pregnancy in mismated dogs. Theriogenology 2006, 66, 1568-1572.
• 23.Van Cruchten S., Van den Broeck W., D'haeseleer M., Simoens P.: Proliferation patterns in the canine endometrium during the estrous cycle. Theriogenology 2004, 62, 631-641.
• 24.Zawistowski S.: Technika histologiczna, histologia oraz podstawy histopatologii. PZWL Warszawa 1970, 67-167.